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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NCOA1 |
Basic gene info. | Gene symbol | NCOA1 |
Gene name | nuclear receptor coactivator 1 | |
Synonyms | F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74 | |
Cytomap | UCSC genome browser: 2p23 | |
Genomic location | chr2 :24807345-24993570 | |
Type of gene | protein-coding | |
RefGenes | NM_003743.4, NM_147223.2,NM_147233.2, | |
Ensembl id | ENSG00000084676 | |
Description | Hin-2 proteinPAX3/NCOA1 fusion proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602691 | |
HGNC : HGNC | ||
Ensembl : ENSG00000084676 | ||
HPRD : 04070 | ||
Vega : OTTHUMG00000125523 | ||
Protein | UniProt: Q15788 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NCOA1 | |
BioGPS: 8648 | ||
Gene Expression Atlas: ENSG00000084676 | ||
The Human Protein Atlas: ENSG00000084676 | ||
Pathway | NCI Pathway Interaction Database: NCOA1 | |
KEGG: NCOA1 | ||
REACTOME: NCOA1 | ||
ConsensusPathDB | ||
Pathway Commons: NCOA1 | ||
Metabolism | MetaCyc: NCOA1 | |
HUMANCyc: NCOA1 | ||
Regulation | Ensembl's Regulation: ENSG00000084676 | |
miRBase: chr2 :24,807,345-24,993,570 | ||
TargetScan: NM_003743 | ||
cisRED: ENSG00000084676 | ||
Context | iHOP: NCOA1 | |
cancer metabolism search in PubMed: NCOA1 | ||
UCL Cancer Institute: NCOA1 | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of NCOA1 in cancer cell metabolism | 1. Qin L, Wu Y-L, Toneff MJ, Li D, Liao L, et al. (2014) NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer research 74: 3477-3488. go to article |
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Phenotypic Information for NCOA1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: NCOA1 |
Familial Cancer Database: NCOA1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | 602691; gene. 602691; gene. |
Orphanet | |
Disease | KEGG Disease: NCOA1 |
MedGen: NCOA1 (Human Medical Genetics with Condition) | |
ClinVar: NCOA1 | |
Phenotype | MGI: NCOA1 (International Mouse Phenotyping Consortium) |
PhenomicDB: NCOA1 |
Mutations for NCOA1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | NCOA1 | chr2 | 24833694 | 24833714 | NCOA1 | chr2 | 24847336 | 24847356 |
ovary | NCOA1 | chr2 | 24853636 | 24853656 | NCOA1 | chr2 | 24854196 | 24854216 |
ovary | NCOA1 | chr2 | 24920955 | 24920975 | NCOA1 | chr2 | 24935959 | 24935979 |
ovary | NCOA1 | chr2 | 24923365 | 24923385 | ATAD2B | chr2 | 24138735 | 24138755 |
ovary | NCOA1 | chr2 | 24972212 | 24972232 | NCOA1 | chr2 | 24972282 | 24972302 |
pancreas | NCOA1 | chr2 | 24813720 | 24813740 | chr2 | 83447869 | 83447889 | |
pancreas | NCOA1 | chr2 | 24871174 | 24871194 | NCOA1 | chr2 | 24871357 | 24871377 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NCOA1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AW204594 | NCOA1 | 8 | 64 | 2 | 24930506 | 24930562 | NCOA1 | 60 | 201 | 2 | 24930307 | 24930448 | |
AY633656 | PAX3 | 1 | 956 | 2 | 223085940 | 223163334 | NCOA1 | 954 | 2861 | 2 | 24949456 | 24991385 | |
AA319820 | NCOA1 | 12 | 124 | 2 | 24992801 | 24992913 | NCOA1 | 123 | 256 | 2 | 24992887 | 24993019 | |
BX099622 | NCOA1 | 1 | 104 | 2 | 24991741 | 24991843 | NOVA1 | 91 | 309 | 14 | 27066721 | 27066939 | |
BQ956364 | PCGF3 | 1 | 165 | 4 | 702588 | 702753 | NCOA1 | 157 | 719 | 2 | 24930064 | 24930624 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=88) | (# total SNVs=27) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:24929877-24929877 | p.S513L | 2 |
chr2:24962316-24962316 | p.R1073W | 2 |
chr2:24974859-24974859 | p.P1239S | 2 |
chr2:24985555-24985555 | p.? | 2 |
chr2:24928097-24928097 | p.I364I | 2 |
chr2:24929991-24929991 | p.S551F | 2 |
chr2:24916179-24916179 | p.T257T | 2 |
chr2:24949464-24949464 | p.P869H | 2 |
chr2:24991150-24991150 | p.D1406Y | 1 |
chr2:24929854-24929854 | p.N505N | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 6 | 2 | 1 | 20 | 1 |   | 8 |   | 3 | 2 |   | 15 | 11 | 3 |   |   | 12 | 15 | 1 | 15 |
# mutation | 8 | 2 | 1 | 22 | 1 |   | 8 |   | 3 | 2 |   | 15 | 12 | 3 |   |   | 14 | 18 | 1 | 22 |
nonsynonymous SNV | 8 | 2 | 1 | 15 | 1 |   | 4 |   | 3 |   |   | 11 | 7 | 2 |   |   | 7 | 13 |   | 19 |
synonymous SNV |   |   |   | 7 |   |   | 4 |   |   | 2 |   | 4 | 5 | 1 |   |   | 7 | 5 | 1 | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:24974859 | p.P1359P,NCOA1 | 2 |
chr2:24985567 | p.P1239S,NCOA1 | 2 |
chr2:24930397 | p.E1354Q,NCOA1 | 1 |
chr2:24952429 | p.I363I,NCOA1 | 1 |
chr2:24888650 | p.S513L,NCOA1 | 1 |
chr2:24928059 | p.S729S,NCOA1 | 1 |
chr2:24929562 | p.D887N,NCOA1 | 1 |
chr2:24930637 | p.D75V,NCOA1 | 1 |
chr2:24964907 | p.P1048P,NCOA1 | 1 |
chr2:24896324 | p.D267G,NCOA1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NCOA1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ASXL2,ATF7,BAZ2B,BIRC6,BMPR2,CREB1,DNAJC27, EXOC6B,GCC2,HEATR5B,ITSN2,KIDINS220,MAP3K2,NCOA1, PUM2,RFX7,RGPD3,RGPD4,UBR3,USP34,ZNF510 | ARHGEF12,ASH1L,ATG2B,ERCC6L2,AGO4,ICE1,KIAA1109, KIAA2026,KMT2E,MYO9A,NCOA1,PIAS1,RANBP2,RGPD3, SEC24B,SON,STAG1,TAB2,XRN1,ZBTB38,ZFX | ||||
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BBX,BMPR2,CLASP1,CRIM1,CRYBG3,FRY,IL6ST, INPP4A,IQSEC1,ITSN2,KIDINS220,NCOA1,PLSCR4,SEC14L1, SETBP1,SIK3,SNRK,SOS1,SYNE1,USP34,WDFY3 | AFF1,ARID1B,ASH1L,CAMTA2,CASZ1,DIDO1,FAM168B, FXR2,GIGYF2,ZSWIM8,KIF13A,MED13L,MIA3,NCOA1, NCOR2,NR2C2,RERE,SEC31A,SETD2,SUPT6H,USP34 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for NCOA1 |
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DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | Q15788; -. |
Chemistry | ChEMBL | CHEMBL2095162; -. |
Chemistry | BindingDB | Q15788; -. |
Chemistry | ChEMBL | CHEMBL2095162; -. |
Organism-specific databases | PharmGKB | PA31470; -. |
Organism-specific databases | PharmGKB | PA31470; -. |
Organism-specific databases | CTD | 8648; -. |
Organism-specific databases | CTD | 8648; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01645 | nuclear receptor coactivator 1 | experimental | Genistein | ![]() | ![]() |
DB04652 | nuclear receptor coactivator 1 | experimental | (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE | ![]() | ![]() |
DB06832 | nuclear receptor coactivator 1 | experimental | 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL | ![]() | ![]() |
DB06875 | nuclear receptor coactivator 1 | experimental | 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE | ![]() | ![]() |
DB06908 | nuclear receptor coactivator 1 | experimental | (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID | ![]() | ![]() |
DB06927 | nuclear receptor coactivator 1 | experimental | [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE | ![]() | ![]() |
DB07009 | nuclear receptor coactivator 1 | experimental | 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL | ![]() | ![]() |
DB07080 | nuclear receptor coactivator 1 | experimental | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | ![]() | ![]() |
DB07119 | nuclear receptor coactivator 1 | experimental | 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL | ![]() | ![]() |
DB07150 | nuclear receptor coactivator 1 | experimental | 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME | ![]() | ![]() |
DB07198 | nuclear receptor coactivator 1 | experimental | 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE | ![]() | ![]() |
DB07215 | nuclear receptor coactivator 1 | experimental | 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID | ![]() | ![]() |
DB07230 | nuclear receptor coactivator 1 | experimental | 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE | ![]() | ![]() |
DB07236 | nuclear receptor coactivator 1 | experimental | 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL | ![]() | ![]() |
DB07530 | nuclear receptor coactivator 1 | experimental | (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol | ![]() | ![]() |
DB07557 | nuclear receptor coactivator 1 | experimental | (5BETA)-PREGNANE-3,20-DIONE | ![]() | ![]() |
DB07724 | nuclear receptor coactivator 1 | experimental | 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid | ![]() | ![]() |
DB08220 | nuclear receptor coactivator 1 | experimental | (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid | ![]() | ![]() |
DB08231 | nuclear receptor coactivator 1 | experimental | MYRISTIC ACID | ![]() | ![]() |
DB08483 | nuclear receptor coactivator 1 | experimental | (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid | ![]() | ![]() |
DB08742 | nuclear receptor coactivator 1 | experimental | 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) | ![]() | ![]() |
DB00755 | nuclear receptor coactivator 1 | approved; nutraceutical; investigational | Tretinoin | ![]() | ![]() |
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Cross referenced IDs for NCOA1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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