|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for EIF3C |
Basic gene info. | Gene symbol | EIF3C |
Gene name | eukaryotic translation initiation factor 3, subunit C | |
Synonyms | EIF3CL|EIF3S8|eIF3-p110 | |
Cytomap | UCSC genome browser: 16p11.2 | |
Genomic location | chr16 :28722781-28747050 | |
Type of gene | protein-coding | |
RefGenes | NM_001037808.2, NM_001199142.1,NM_001267574.2,NM_001286478.1,NM_003752.4, | |
Ensembl id | ENSG00000184110 | |
Description | cell migration-inducing protein 17eIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3 subunit Ceukaryotic translation initiation factor 3, subunit 8 (110kD)eukaryotic translation initiation factor 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603916 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184110 | ||
HPRD : 04889 | ||
Vega : OTTHUMG00000099443 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_EIF3C | |
BioGPS: 8663 | ||
Gene Expression Atlas: ENSG00000184110 | ||
The Human Protein Atlas: ENSG00000184110 | ||
Pathway | NCI Pathway Interaction Database: EIF3C | |
KEGG: EIF3C | ||
REACTOME: EIF3C | ||
ConsensusPathDB | ||
Pathway Commons: EIF3C | ||
Metabolism | MetaCyc: EIF3C | |
HUMANCyc: EIF3C | ||
Regulation | Ensembl's Regulation: ENSG00000184110 | |
miRBase: chr16 :28,722,781-28,747,050 | ||
TargetScan: NM_001037808 | ||
cisRED: ENSG00000184110 | ||
Context | iHOP: EIF3C | |
cancer metabolism search in PubMed: EIF3C | ||
UCL Cancer Institute: EIF3C | ||
Assigned class in ccmGDB | C |
Top |
Phenotypic Information for EIF3C(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: EIF3C |
Familial Cancer Database: EIF3C |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: EIF3C |
MedGen: EIF3C (Human Medical Genetics with Condition) | |
ClinVar: EIF3C | |
Phenotype | MGI: EIF3C (International Mouse Phenotyping Consortium) |
PhenomicDB: EIF3C |
Mutations for EIF3C |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | EIF3C | chr16 | 28710844 | 28710864 | ENPP1 | chr6 | 132211113 | 132211133 |
pancreas | EIF3C | chr16 | 28741373 | 28741393 | SHCBP1 | chr16 | 46632066 | 46632086 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EIF3C related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=12) | (# total SNVs=3) |
(# total SNVs=0) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:28734640-28734640 | p.V311G | 2 |
chr16:28734620-28734620 | p.V304V | 1 |
chr16:28735765-28735765 | p.N388T | 1 |
chr16:28734621-28734621 | p.R305W | 1 |
chr16:28736317-28736317 | p.T462T | 1 |
chr16:28734622-28734622 | p.R305L | 1 |
chr16:28734626-28734626 | p.G306G | 1 |
chr16:28734627-28734627 | p.G307* | 1 |
chr16:28734540-28734540 | p.A278T | 1 |
chr16:28734633-28734633 | p.P309T | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
# mutation |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
Other DBs for Point Mutations |
Copy Number for EIF3C in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for EIF3C |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ADAM17,ANLN,COA7,CENPO,CKAP2L,CLSPN,DEPDC1, EIF3C,FAM83D,GART,GSG2,MSH6,NUP155,ORC1, PLK1,POLR1A,RNF168,SKP2,STIL,WDR43,XPO5 | CCL18,CDRT15,CETP,EIF3C,GAD2,GAP43,HMOX1, LOC150527,LRIT1,OR2AG1,OR8D1,RHOXF2B,SNORA19,SNORA21, SPATA8,SPRR2F,SPRR2G,TECTB,TMEM114,VENTXP1,WNT1 |
EIF3C,HIST1H4K,LCE2B,FTX,OR6N2,OR8B3,POTEE, PPIAL4B,PRAMEF17,PRAMEF3,REXO1L1P,SNORA38,SNORD16,SNORD35B, SNORD88C,TP | BAG5,BPY2,CTRB1,EIF3C,FMO6P,FOSL1,FUT5, GCM2,GJA3,GSTTP2,HAS1,KRT78,MESDC1,METTL11B, MMP13,OR2T12,OR52M1,PNPLA5,SEC14L3,SYCN,TFDP3 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for EIF3C |
There's no related Drug. |
Top |
Cross referenced IDs for EIF3C |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |