Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for HYAL2
Basic gene info.Gene symbolHYAL2
Gene namehyaluronoglucosaminidase 2
SynonymsLUCA2
CytomapUCSC genome browser: 3p21.3
Genomic locationchr3 :50355220-50360281
Type of geneprotein-coding
RefGenesNM_003773.4,
NM_033158.4,
Ensembl idENSG00000261921
DescriptionPH-20 homologPH20 homologhyal-2hyaluronidase 2hyaluronidase-2hyaluronoglucosaminidase-2lung carcinoma protein 2lysosomal hyaluronidase
Modification date20141207
dbXrefs MIM : 603551
HGNC : HGNC
Ensembl : ENSG00000068001
HPRD : 04649
Vega : OTTHUMG00000156876
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HYAL2
BioGPS: 8692
Gene Expression Atlas: ENSG00000261921
The Human Protein Atlas: ENSG00000261921
PathwayNCI Pathway Interaction Database: HYAL2
KEGG: HYAL2
REACTOME: HYAL2
ConsensusPathDB
Pathway Commons: HYAL2
MetabolismMetaCyc: HYAL2
HUMANCyc: HYAL2
RegulationEnsembl's Regulation: ENSG00000261921
miRBase: chr3 :50,355,220-50,360,281
TargetScan: NM_003773
cisRED: ENSG00000261921
ContextiHOP: HYAL2
cancer metabolism search in PubMed: HYAL2
UCL Cancer Institute: HYAL2
Assigned class in ccmGDBC

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Phenotypic Information for HYAL2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: HYAL2
Familial Cancer Database: HYAL2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_HYALURONAN_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: HYAL2
MedGen: HYAL2 (Human Medical Genetics with Condition)
ClinVar: HYAL2
PhenotypeMGI: HYAL2 (International Mouse Phenotyping Consortium)
PhenomicDB: HYAL2

Mutations for HYAL2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HYAL2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CF131370HYAL2111935035715350357271HYAL211480735035755850358599
BF853827IGFBP7923445793940357939632HYAL221860335035527850355662

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=24)
Stat. for Synonymous SNVs
(# total SNVs=12)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=2)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr3:50357869-50357869p.S18A4
chr3:50355723-50355723p.H420R2
chr3:50357321-50357321p.R200R2
chr3:50357654-50357654p.F89F2
chr3:50357666-50357666p.L85L2
chr3:50357183-50357183p.T246T1
chr3:50355710-50355710p.H424Q1
chr3:50357575-50357575p.R116C1
chr3:50356398-50356398p.T334A1
chr3:50357873-50357873p.A16A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample22 3  1 1  1 1  26 4
# mutation22 4  1 1  1 1  37 4
nonsynonymous SNV22 2  1 1  1    16 3
synonymous SNV   2         1  21 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr3:50355943p.R277C,HYAL21
chr3:50357479p.A27T,HYAL21
chr3:50357070p.H263D,HYAL21
chr3:50357493p.A20V,HYAL21
chr3:50357092p.P250T,HYAL21
chr3:50357533p.A16A,HYAL21
chr3:50357134p.D229N,HYAL21
chr3:50357640p.S222I,HYAL21
chr3:50357173p.R192C,HYAL21
chr3:50357653p.F181F,HYAL21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for HYAL2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HYAL2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACVRL1,ADCY4,CLDN5,CLEC14A,ENG,ESAM,EXOC3L1,
EXOC3L2,TMEM255B,GJA4,GNAI2,GRASP,HYAL2,KANK3,
NOVA2,PLVAP,ROBO4,SCARF1,TIE1,TMEM88,USHBP1
A4GALT,ADAM15,ADRA2C,APOL1,C10orf54,PRR29,DHH,
E2F4,GNAI2,HLA-E,HYAL2,NNMT,NOS3,PLVAP,
RAMP3,RASIP1,SEMA6B,SH2D3C,SLCO4A1,SPNS2,TNFRSF1A

CALCRL,CLEC14A,CNRIP1,CXorf36,ECSCR,ELTD1,GJA4,
GJA5,GNG11,GPX7,HYAL2,IGFBP7,LGALS1,MCAM,
PCDH12,RAMP2,RASIP1,RHOJ,S1PR1,TIE1,TMEM204
AEN,ARID5A,EVA1C,CCDC86,DDX21,GNL2,GTPBP4,
HYAL2,LTV1,MAK16,METTL1,NNMT,NOP16,ODC1,
PNO1,PUS1,PYCRL,SLC25A32,TRMT6,ZPR1,ZNF593
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HYAL2


There's no related Drug.
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Cross referenced IDs for HYAL2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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