Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for FBP2
Basic gene info.Gene symbolFBP2
Gene namefructose-1,6-bisphosphatase 2
Synonyms-
CytomapUCSC genome browser: 9q22.3
Genomic locationchr9 :97321002-97356075
Type of geneprotein-coding
RefGenesNM_003837.3,
Ensembl idENSG00000130957
DescriptionD-fructose-1,6-bisphosphate 1-phosphohydrolase 2FBPase 2fructose-1,6-bisphosphatase isozyme 2hexosediphosphatasemuscle FBPasemuscle fructose-bisphosphatase
Modification date20141207
dbXrefs MIM : 603027
HGNC : HGNC
Ensembl : ENSG00000130957
HPRD : 04322
Vega : OTTHUMG00000020269
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FBP2
BioGPS: 8789
Gene Expression Atlas: ENSG00000130957
The Human Protein Atlas: ENSG00000130957
PathwayNCI Pathway Interaction Database: FBP2
KEGG: FBP2
REACTOME: FBP2
ConsensusPathDB
Pathway Commons: FBP2
MetabolismMetaCyc: FBP2
HUMANCyc: FBP2
RegulationEnsembl's Regulation: ENSG00000130957
miRBase: chr9 :97,321,002-97,356,075
TargetScan: NM_003837
cisRED: ENSG00000130957
ContextiHOP: FBP2
cancer metabolism search in PubMed: FBP2
UCL Cancer Institute: FBP2
Assigned class in ccmGDBC

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Phenotypic Information for FBP2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: FBP2
Familial Cancer Database: FBP2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCOLYSIS_GLUCONEOGENESIS
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: FBP2
MedGen: FBP2 (Human Medical Genetics with Condition)
ClinVar: FBP2
PhenotypeMGI: FBP2 (International Mouse Phenotyping Consortium)
PhenomicDB: FBP2

Mutations for FBP2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FBP2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample 1   1           
GAIN (# sample)                 
LOSS (# sample) 1   1           
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=23)
Stat. for Synonymous SNVs
(# total SNVs=14)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:97321261-97321261p.E327*3
chr9:97329591-97329591p.A222A2
chr9:97355890-97355890p.T40M2
chr9:97333768-97333768p.G181G2
chr9:97321259-97321259p.E327D2
chr9:97333797-97333797p.T172A1
chr9:97321316-97321316p.P308P1
chr9:97349727-97349727p.N65N1
chr9:97356002-97356002p.D3N1
chr9:97329575-97329575p.V228M1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample   83 1    32   64 5
# mutation   83 1    32   65 5
nonsynonymous SNV   51 1    11   34 2
synonymous SNV   32      21   31 3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:97333768p.G181G2
chr9:97349699p.R277R1
chr9:97321399p.D146D1
chr9:97333780p.T256T1
chr9:97349706p.I139M1
chr9:97321409p.H254N1
chr9:97333785p.I127I1
chr9:97349721p.V246A1
chr9:97325681p.D102D1
chr9:97333797p.F233F1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for FBP2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FBP2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADH7,BTG2,ACSM6,C15orf48,AXDND1,CCNI2,EPHA8,
ABHD17B,FBP2,FOXE1,HOXB8,IL36A,NIM1K,MYCL,
PPARG,PSCA,SFTPA1,SFTPB,TIMP4,TMPRSS11B,TOB2
ACTA1,ACTN2,ATP2A1,C10orf71,MIR1-1HG,CACNA1S,CKM,
CSRP3,ENO3,FBP2,HFE2,LMOD2,MYH2,MYH6,
MYH7,MYL1,MYL2,MYLPF,NRAP,PPP1R3A,TECRL

ADCY10,ASUN,C12orf71,CASC1,DLK1,FBP2,FGFR1OP2,
GPR112,GRK1,KLHL42,KRAS,LYRM5,MED21,MRPS35,
NR5A1,PROL1,SLC23A3,STAR,STK38L,TM
GGACT,ARGFX,BPY2,C1orf100,CTRB1,FBP2,FUT5,
GJA3,KRT78,LANCL2,LOC723809,MARS2,MMP13,NLRP10,
NRG1,OR2T12,OR52M1,PNPLA5,RHO,SYCN,TSGA13
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FBP2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00121fructose-1,6-bisphosphatase 2approved; nutraceuticalBiotin


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Cross referenced IDs for FBP2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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