|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for INPP4B |
Basic gene info. | Gene symbol | INPP4B |
Gene name | inositol polyphosphate-4-phosphatase, type II, 105kDa | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q31.21 | |
Genomic location | chr4 :142949181-143767604 | |
Type of gene | protein-coding | |
RefGenes | NM_001101669.1, NM_003866.2, | |
Ensembl id | ENSG00000109452 | |
Description | inositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate 4-phosphatase type IIinositol polyphosphate-4-phosphatase, type II, 105kDtype II inositol 3,4-bisphosphate 4-phosphatasetype II inositol-3,4-bisphosphate 4-phosphatase | |
Modification date | 20141207 | |
dbXrefs | MIM : 607494 | |
HGNC : HGNC | ||
Ensembl : ENSG00000109452 | ||
HPRD : 06322 | ||
Vega : OTTHUMG00000161341 | ||
Protein | UniProt: O15327 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_INPP4B | |
BioGPS: 8821 | ||
Gene Expression Atlas: ENSG00000109452 | ||
The Human Protein Atlas: ENSG00000109452 | ||
Pathway | NCI Pathway Interaction Database: INPP4B | |
KEGG: INPP4B | ||
REACTOME: INPP4B | ||
ConsensusPathDB | ||
Pathway Commons: INPP4B | ||
Metabolism | MetaCyc: INPP4B | |
HUMANCyc: INPP4B | ||
Regulation | Ensembl's Regulation: ENSG00000109452 | |
miRBase: chr4 :142,949,181-143,767,604 | ||
TargetScan: NM_001101669 | ||
cisRED: ENSG00000109452 | ||
Context | iHOP: INPP4B | |
cancer metabolism search in PubMed: INPP4B | ||
UCL Cancer Institute: INPP4B | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of INPP4B in cancer cell metabolism | 1. Min JW, Kim KI, Kim HA, Kim EK, Noh WC, et al. (2013) INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells. Biochem Biophys Res Commun 440: 137-142. doi: 10.1016/j.bbrc.2013.09.041. go to article 2. Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, et al. (2013) Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. Biochem Biophys Res Commun 440: 277-282. doi: 10.1016/j.bbrc.2013.09.077. go to article 3. Zhang X, Chen H, Wang X, Zhao W, Chen JJ (2014) Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells. Gynecol Oncol 134: 372-378. doi: 10.1016/j.ygyno.2014.04.050. go to article |
Top |
Phenotypic Information for INPP4B(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: INPP4B |
Familial Cancer Database: INPP4B |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_INOSITOL_PHOSPHATE_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_PI_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
![]() | |
OMIM | 607494; gene. |
Orphanet | |
Disease | KEGG Disease: INPP4B |
MedGen: INPP4B (Human Medical Genetics with Condition) | |
ClinVar: INPP4B | |
Phenotype | MGI: INPP4B (International Mouse Phenotyping Consortium) |
PhenomicDB: INPP4B |
Mutations for INPP4B |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
- Statistics for Tissue and Mutation type | Top |
![]() |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
![]() |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
![]() |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | INPP4B | chr4 | 142966858 | 142966878 | chr4 | 142708424 | 142708444 | |
ovary | INPP4B | chr4 | 143112579 | 143112599 | chr8 | 42120902 | 42120922 | |
ovary | INPP4B | chr4 | 143112771 | 143112791 | SLC20A2 | chr8 | 42289672 | 42289692 |
ovary | INPP4B | chr4 | 143162513 | 143162533 | INPP4B | chr4 | 143158755 | 143158775 |
ovary | INPP4B | chr4 | 143353923 | 143353943 | chr4 | 144708014 | 144708034 | |
ovary | INPP4B | chr4 | 143376718 | 143376738 | INPP4B | chr4 | 143373158 | 143373178 |
ovary | INPP4B | chr4 | 143502810 | 143502830 | DEPTOR | chr8 | 121037892 | 121037912 |
pancreas | INPP4B | chr4 | 142971601 | 142971621 | INPP4B | chr4 | 142971722 | 142971742 |
pancreas | INPP4B | chr4 | 142975114 | 142975134 | INPP4B | chr4 | 142975210 | 142975230 |
pancreas | INPP4B | chr4 | 143018635 | 143018655 | chr4 | 155616362 | 155616382 | |
pancreas | INPP4B | chr4 | 143044679 | 143044699 | INPP4B | chr4 | 143046841 | 143046861 |
pancreas | INPP4B | chr4 | 143130541 | 143130561 | INPP4B | chr4 | 143617879 | 143617899 |
pancreas | INPP4B | chr4 | 143598663 | 143598683 | INPP4B | chr4 | 143578418 | 143578438 |
pancreas | INPP4B | chr4 | 143756618 | 143756638 | GAB1 | chr4 | 144393092 | 144393112 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INPP4B related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
DB020243 | INPP4B | 1 | 239 | 4 | 143687891 | 143689122 | IST1 | 237 | 544 | 16 | 71924472 | 71928762 | |
BP360877 | MAPK10 | 1 | 511 | 4 | 87275682 | 87281206 | INPP4B | 510 | 582 | 4 | 143067074 | 143067145 | |
AK057258 | INPP4B | 1 | 238 | 4 | 143687891 | 143689122 | IST1 | 236 | 1735 | 16 | 71924472 | 71961793 | |
CB044109 | INPP4B | 189 | 243 | 4 | 142963302 | 142963356 | GPX3 | 242 | 672 | 5 | 150406475 | 150407696 | |
BG990026 | INPP4B | 17 | 36 | 4 | 142957046 | 142957065 | ELL3 | 30 | 318 | 15 | 44084546 | 44086052 | |
S60878 | INPP4B | 8 | 34 | 4 | 143719085 | 143719135 | WBSCR17 | 15 | 35 | 7 | 70897786 | 70897806 | |
BF895764 | SKAP2 | 31 | 441 | 7 | 26813062 | 26813470 | INPP4B | 436 | 488 | 4 | 143233000 | 143233052 | |
BG952183 | EGFLAM | 119 | 156 | 5 | 38320667 | 38320731 | INPP4B | 143 | 311 | 4 | 143072468 | 143072636 |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 3 | 1 |   | 1 |   |   | 5 |   | 2 |   | 3 |   |   | 2 | 2 |   | 4 | |||
GAIN (# sample) | 2 |   |   | 1 |   |   | 3 |   | 2 |   | 2 |   |   | 1 | 1 |   | 2 | |||
LOSS (# sample) | 1 | 1 |   |   |   |   | 2 |   |   |   | 1 |   |   | 1 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=111) | (# total SNVs=29) |
![]() | ![]() |
(# total SNVs=2) | (# total SNVs=3) |
![]() | ![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:143081713-143081713 | p.T454R | 4 |
chr4:143159105-143159105 | p.R250* | 4 |
chr4:143324153-143324153 | p.I104V | 4 |
chr4:143067097-143067097 | p.V539A | 3 |
chr4:143029297-143029297 | p.E775K | 3 |
chr4:143094806-143094806 | p.S446S | 3 |
chr4:142950014-142950014 | p.A899V | 2 |
chr4:143235881-143235881 | p.P136L | 2 |
chr4:142950056-142950056 | p.R885H | 2 |
chr4:143235911-143235911 | p.R126Q | 2 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 5 | 6 |   | 13 |   |   | 6 |   | 2 | 1 |   | 20 | 4 | 2 |   |   | 3 | 8 |   | 15 |
# mutation | 5 | 6 |   | 15 |   |   | 7 |   | 2 | 1 |   | 21 | 5 | 2 |   |   | 3 | 9 |   | 17 |
nonsynonymous SNV | 3 | 5 |   | 11 |   |   | 6 |   | 1 | 1 |   | 14 | 5 | 2 |   |   | 2 | 6 |   | 11 |
synonymous SNV | 2 | 1 |   | 4 |   |   | 1 |   | 1 |   |   | 7 |   |   |   |   | 1 | 3 |   | 6 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:143029297 | p.E775K,INPP4B | 3 |
chr4:143181714 | p.R250Q,INPP4B | 2 |
chr4:143159104 | p.L809I,INPP4B | 2 |
chr4:143181690 | p.P215T,INPP4B | 2 |
chr4:143007359 | p.A207S,INPP4B | 2 |
chr4:143043380 | p.Y105Y,INPP4B | 1 |
chr4:143129678 | p.M879I,INPP4B | 1 |
chr4:143350350 | p.F746F,INPP4B | 1 |
chr4:142950056 | p.D540G,INPP4B | 1 |
chr4:143067052 | p.V366V,INPP4B | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for INPP4B |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
Top |
![]() |
*RPPA protein expression data were extracted from TCPA (The Cancer Proteome Atlas). Normalized data based on replicated based normalization (RBN) was used to draw following figures. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |
AFF1,AHNAK,ARFIP1,ATG2B,BOD1L1,SMIM14,CREBRF, CCNG2,FNIP1,INPP4B,KIAA0232,KIAA1109,LCOR,LRBA, MAP3K1,MKL2,PTPN13,RAB27B,STAM2,WDFY3,ZNF844 | AFF3,ANKRD30A,ANKS1B,ARHGAP32,ERBB4,FAM161B,IGF1R, INPP4B,IQCH,LYPD6,MAGI3,MYB,MYO6,JADE3, RAB27B,RABEP1,RASEF,ST8SIA6,SYTL2,SYTL5,TSPAN5 |
![]() | |
ACTBL2,ANXA8,BPI,C8orf86,CGB1,CPA4,CST6, FAM3C,IL20RB,INPP4B,LIPK,LRAT,MUC16,MYH16, PEX5L,PSG6,PSG9,SIGLEC15,THEG,WNT7A,ZNF365 | CAST,CEBPG,CORO2A,DHCR24,GPD2,INPP4B,KIF16B, LHFPL2,LUZP1,PICALM,PLS1,PSMD11,RAB14,RNF103, SLC41A2,SMAP1,TMEM135,TOP1P1,UGCG,VDAC1,ZDHHC21 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for INPP4B |
There's no related Drug. |
Top |
Cross referenced IDs for INPP4B |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |