Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for ALDH1A2

Basic gene info.	Gene symbol	ALDH1A2
	Gene name	aldehyde dehydrogenase 1 family, member A2
	Synonyms	RALDH(II)\|RALDH2\|RALDH2-T
	Cytomap	UCSC genome browser: 15q21.3
	Genomic location	chr15 :58245621-58358121
	Type of gene	protein-coding
	RefGenes	NM_001206897.1, NM_003888.3,NM_170696.2,NM_170697.2,
	Ensembl id	ENSG00000128918
	Description	RALDH 2retinal dehydrogenase 2retinaldehyde-specific dehydrogenase type 2
	Modification date	20141207
dbXrefs	MIM : 603687
	HGNC : HGNC
	Ensembl : ENSG00000128918
	HPRD : 04733
	Vega : OTTHUMG00000132624
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ALDH1A2
	BioGPS: 8854
	Gene Expression Atlas: ENSG00000128918
	The Human Protein Atlas: ENSG00000128918
Pathway	NCI Pathway Interaction Database: ALDH1A2
	KEGG: ALDH1A2
	REACTOME: ALDH1A2
	ConsensusPathDB
	Pathway Commons: ALDH1A2
Metabolism	MetaCyc: ALDH1A2
	HUMANCyc: ALDH1A2
Regulation	Ensembl's Regulation: ENSG00000128918
	miRBase: chr15 :58,245,621-58,358,121
	TargetScan: NM_001206897
	cisRED: ENSG00000128918
Context	iHOP: ALDH1A2
	cancer metabolism search in PubMed: ALDH1A2
	UCL Cancer Institute: ALDH1A2
Assigned class in ccmGDB	C

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Phenotypic Information for ALDH1A2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: ALDH1A2
	Familial Cancer Database: ALDH1A2

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_RETINOL_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: ALDH1A2
	MedGen: ALDH1A2 (Human Medical Genetics with Condition)
	ClinVar: ALDH1A2
Phenotype	MGI: ALDH1A2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: ALDH1A2

Mutations for ALDH1A2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALDH1A2 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG231914	PNPO	14	163	17	46025502	46025651	ALDH1A2	161	457	15	58245801	58246097
BM677567	ALDH1A2	18	204	15	58245627	58245813	IGFBP5	199	634	2	217541019	217541455

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=57)	Stat. for Synonymous SNVs (# total SNVs=16)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr15:58302898-58302898	p.R148*	3
chr15:58256130-58256130	p.R347C	2
chr15:58287308-58287308	p.E175K	2
chr15:58256142-58256142	p.R343W	2
chr15:58287313-58287313	p.R173I	2
chr15:58285176-58285176	p.L217L	2
chr15:58253334-58253334	p.?	2
chr15:58357797-58357797	p.A18T	2
chr15:58256196-58256196	p.R325C	2
chr15:58306099-58306099	p.D107G	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2	1	1	18	3		4		1			8	5			1	15	9		8
# mutation	2	1	1	17	3		4		1			9	4			1	15	11		12
nonsynonymous SNV	1	1	1	15	2		4		1			8	4			1	10	7		9
synonymous SNV	1			2	1							1					5	4		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr15:58357797	p.A18T,ALDH1A2	2
chr15:58306099	p.V47I,ALDH1A2	2
chr15:58247467	p.R251C,ALDH1A2	2
chr15:58285260	p.M399I,ALDH1A2	2
chr15:58302913	p.P93P,ALDH1A2	2
chr15:58256130	p.H24R,ALDH1A2	2
chr15:58357778	p.D11G,ALDH1A2	2
chr15:58287308	p.E79K,ALDH1A2	2
chr15:58256142	p.R8H,ALDH1A2	1
chr15:58302943	p.A21V,ALDH1A2	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for ALDH1A2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ALDH1A2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ALDH1A2,FAM227B,CDAN1,COPS2,CYP2C9,DTWD1,FLJ10038, GALK2,HAUS2,HK1,LRRC57,ICE2,PIGB,BLOC1S6, PRTG,RSL24D1,SPANXD,SPATA5L1,SUPV3L1,TCTN3,VPS26A	ALDH1A2,ANO4,BSX,CDK15,COL1A2,COL3A1,COL5A2, COL6A6,DBX2,DCHS1,KCNA1,MAP1A,NGF,NID1, NPC1L1,OR5M8,THBS2,TNFRSF8,TRPC5,WBSCR17,WNT2

ALDH1A2,BOLL,CHRM4,CRISP1,CYMP,EPHA8,FGF5, HTR1B,ITLN1,KDELR3,MAGEB10,PCDHAC1,POTEC,PRSS41, RBP3,SEPT12,SLC2A10,SPINK4,ST8SIA2,TBC1D2,ZNF488	ALDH1A2,ARMC4,CCDC144NL,CD300LG,CDH3,CHRDL2,CST11, DOC2B,FAM169B,FAP,FCN3,MARCO,P4HA3,SBSN, SPINK4,TIMP1,TNIP3,

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ALDH1A2

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00157	aldehyde dehydrogenase 1 family, member A2	approved; nutraceutical	NADH
DB00162	aldehyde dehydrogenase 1 family, member A2	approved; nutraceutical	Vitamin A
DB00755	aldehyde dehydrogenase 1 family, member A2	approved; nutraceutical; investigational	Tretinoin
DB01907	aldehyde dehydrogenase 1 family, member A2	experimental	Nicotinamide-Adenine-Dinucleotide

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Cross referenced IDs for ALDH1A2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information