Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

Home

	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for GYG2

Basic gene info.	Gene symbol	GYG2
	Gene name	glycogenin 2
	Synonyms	GN-2\|GN2
	Cytomap	UCSC genome browser: Xp22.3
	Genomic location	chrX :2746862-2800861
	Type of gene	protein-coding
	RefGenes	NM_001079855.1, NM_001184702.1,NM_001184703.1,NM_001184704.1,NM_003918.2,
	Ensembl id	ENSG00000056998
	Description	glycogenin glucosyltransferaseglycogenin-2
	Modification date	20141207
dbXrefs	MIM : 300198
	HGNC : HGNC
	Ensembl : ENSG00000056998
	HPRD : 02185
	Vega : OTTHUMG00000021079
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GYG2
	BioGPS: 8908
	Gene Expression Atlas: ENSG00000056998
	The Human Protein Atlas: ENSG00000056998
Pathway	NCI Pathway Interaction Database: GYG2
	KEGG: GYG2
	REACTOME: GYG2
	ConsensusPathDB
	Pathway Commons: GYG2
Metabolism	MetaCyc: GYG2
	HUMANCyc: GYG2
Regulation	Ensembl's Regulation: ENSG00000056998
	miRBase: chrX :2,746,862-2,800,861
	TargetScan: NM_001079855
	cisRED: ENSG00000056998
Context	iHOP: GYG2
	cancer metabolism search in PubMed: GYG2
	UCL Cancer Institute: GYG2
Assigned class in ccmGDB	C

Top

Phenotypic Information for GYG2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: GYG2
	Familial Cancer Database: GYG2

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES REACTOME_GLUCOSE_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: GYG2
	MedGen: GYG2 (Human Medical Genetics with Condition)
	ClinVar: GYG2
Phenotype	MGI: GYG2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: GYG2

Mutations for GYG2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GYG2 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BF309900	GYG2	2	75	X	2761351	2772049	GYG2	66	678	X	2772129	2779598
U94359	EMB	1	2646	5	49693861	49707829	GYG2	2640	4066	X	2798741	2800155

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

Top

Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

Top

SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

Top

Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=36)	Stat. for Synonymous SNVs (# total SNVs=13)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

Top

Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr23:2795286-2795286	p.E428K	3
chr23:2772118-2772118	p.G114R	2
chr23:2795308-2795308	p.A435D	2
chr23:2761348-2761348	p.T65T	2
chr23:2773087-2773087	p.P157P	2
chr23:2761050-2761050	p.H7Y	2
chr23:2778030-2778030	p.T285M	2
chr23:2772094-2772094	p.A106T	1
chr23:2773121-2773121	p.V169L	1
chr23:2761306-2761306	p.G51G	1

Top

SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		3		7	2		1			1		2	4	1			2	2		5
# mutation		3		8	2		1			1		2	4	1			2	2		5
nonsynonymous SNV		2		5			1			1		2	3	1			1	2		4
synonymous SNV		1		3	2								1				1			1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top

Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chrX:2772118	p.G83R,GYG2	2
chrX:2761348	p.T34T,GYG2	2
chrX:2773121	p.A114E,GYG2	1
chrX:2779655	p.L86F,GYG2	1
chrX:2772026	p.P155P,GYG2	1
chrX:2773149	p.V109V,GYG2	1
chrX:2779761	p.D191Y,GYG2	1
chrX:2772069	p.D114N,GYG2	1
chrX:2773196	p.V387V,GYG2	1
chrX:2795258	p.A124V,GYG2	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for GYG2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top

Gene Expression for GYG2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

Top

CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

Top

Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACVR1C,ADH1A,ADH1B,ADIPOQ,AOC3,AQP7,AQPEP, C14orf180,CIDEC,GLYAT,GPD1,GYG2,HEPACAM,HEPN1, KCNIP2,KLB,LIPE,PLIN1,PLIN4,SLC19A3,TMEM132C	ABHD15,ACO1,FAM213A,CIDEC,ESYT1,FAM89A,FBXO27, GNAI1,GYG2,HEPACAM,HRASLS5,KCNIP2,LPL,MARC1, PDE3B,PECR,PEX19,PLIN1,PPARG,SIK2,TYRO3

ARSE,CTPS2,EIF1AX,FARP1,FUNDC1,GEMIN8,GYG2, HDHD1,KDM5C,NAALADL2,OFD1,JADE3,RNF43,SCML1, SHROOM4,SYAP1,TAB3,TXLNG,XIST,ZBED1,ZRSR2	CDC25B,CHI3L1,CLEC4GP1,CPXM1,CST11,DPPA3,DPYS, GYG2,LOC55908,LOC728723,LPL,MARCO,NKX6-2,PCSK9, PLTP,REG1A,REG1B,RNASE2,SCD,SLC7A10,THRSP

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

Top

Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top

Pharmacological Information for GYG2

There's no related Drug.

Top

Cross referenced IDs for GYG2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information