Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for KYNU
Basic gene info.Gene symbolKYNU
Gene namekynureninase
SynonymsKYNUU
CytomapUCSC genome browser: 2q22.2
Genomic locationchr2 :143635194-143747106
Type of geneprotein-coding
RefGenesNM_001032998.1,
NM_001199241.1,NM_003937.2,
Ensembl idENSG00000115919
DescriptionL-kynurenine hydrolase
Modification date20141207
dbXrefs MIM : 605197
HGNC : HGNC
Ensembl : ENSG00000115919
HPRD : 08940
Vega : OTTHUMG00000131829
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KYNU
BioGPS: 8942
Gene Expression Atlas: ENSG00000115919
The Human Protein Atlas: ENSG00000115919
PathwayNCI Pathway Interaction Database: KYNU
KEGG: KYNU
REACTOME: KYNU
ConsensusPathDB
Pathway Commons: KYNU
MetabolismMetaCyc: KYNU
HUMANCyc: KYNU
RegulationEnsembl's Regulation: ENSG00000115919
miRBase: chr2 :143,635,194-143,747,106
TargetScan: NM_001032998
cisRED: ENSG00000115919
ContextiHOP: KYNU
cancer metabolism search in PubMed: KYNU
UCL Cancer Institute: KYNU
Assigned class in ccmGDBC

Top
Phenotypic Information for KYNU(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: KYNU
Familial Cancer Database: KYNU
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_TRYPTOPHAN_METABOLISM
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: KYNU
MedGen: KYNU (Human Medical Genetics with Condition)
ClinVar: KYNU
PhenotypeMGI: KYNU (International Mouse Phenotyping Consortium)
PhenomicDB: KYNU

Mutations for KYNU
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
There's no intra-chromosomal structural variation.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryKYNUchr2143642601143642621KYNUchr2143651108143651128
pancreasKYNUchr2143642540143642560KYNUchr2143642713143642733
prostateKYNUchr2143744304143744304chr127179690071796900
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows KYNU related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BP333200HTN1135947091615570924377KYNU3533742143795116143795138
BF997792TGOLN2118128554796685548146KYNU1743162143725826143725968
BF907726KYNU14902143743515143743591KYNU903272143712379143718221
CB851853KYNU132892143746830143747106KYNU2863772143746729143746820

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample 1      1       2
GAIN (# sample) 1      1       1
LOSS (# sample)                1
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=60)
Stat. for Synonymous SNVs
(# total SNVs=14)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:143643019-143643019p.R28K4
chr2:143713800-143713800p.R155Q3
chr2:143643073-143643073p.F46Y3
chr2:143743579-143743579p.T297T3
chr2:143676226-143676226p.G73E2
chr2:143718341-143718341p.?2
chr2:143676232-143676232p.S75Y2
chr2:143742717-143742717p.W265*2
chr2:143712381-143712381p.A126T2
chr2:143713833-143713833p.P166H2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 101 61 1 1641 1147 7
# mutation 1 121 61 1 1841 1137 7
nonsynonymous SNV 1 81 41 1 1131 194 6
synonymous SNV   4  2    71   43 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:143743579p.T297T,KYNU3
chr2:143676239p.I204M,KYNU2
chr2:143718222p.G73E,KYNU2
chr2:143746426p.G77G,KYNU2
chr2:143676226p.F305L2
chr2:143742735p.L6I,KYNU1
chr2:143712389p.T111T,KYNU1
chr2:143798011p.E194E,KYNU1
chr2:143642952p.G304E,KYNU1
chr2:143715284p.V435V,KYNU1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for KYNU in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for KYNU

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACSM1,ALOX15B,CLDN8,FCN2,FKBP5,G6PD,GGT1,
GGT3P,GRAMD2,ISX,KMO,KYNU,MPV17L,OXER1,
PNLIPRP3,SERHL2,SLCO1B1,SPINK8,SRD5A1,SULT1C2,SULT1C3
ABCC11,ADAM2,AFMID,ALOX15B,C15orf43,DHRS2,GGT1,
GGTLC2,HMGCS2,HPGD,IDI1,KYNU,LST-3TM12,MPV17L,
PNLIPRP3,SERHL2,SERHL,SPINK8,SRD5A1,TARP,UGT2B10

ARL4C,BEAN,C20orf197,CD274,GBP1,HAPLN3,HLA-DRB6,
IL17C,IL23A,IL31RA,KYNU,LCE1F,LETM2,LOC153910,
LOC285735,PLAU,PMAIP1,SERPINB9,TNFAIP2,TYMP,UBASH3B
AIF1,C1orf162,CCR1,CD40,CD86,CYBB,DOK2,
FCER1G,GIMAP4,GNA15,INSL4,KYNU,LILRB2,LILRB4,
NCF2,PDCD1LG2,PLEK,SIGLEC9,SPI1,TMEM106A,TNFSF13B
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for KYNU
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00114kynureninasenutraceuticalPyridoxal Phosphate
DB00160kynureninaseapproved; nutraceuticalL-Alanine
DB07069kynureninaseexperimental3-Hydroxyhippuric acid
DB02343kynureninaseexperimental3,6,9,12,15-Pentaoxaheptadecane
DB00130kynureninaseapproved; nutraceutical; investigationalL-Glutamine
DB00150kynureninaseapproved; nutraceuticalL-Tryptophan


Top
Cross referenced IDs for KYNU
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas