Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for G6PC3
Basic gene info.Gene symbolG6PC3
Gene nameglucose 6 phosphatase, catalytic, 3
SynonymsSCN4|UGRP
CytomapUCSC genome browser: 17q21.31
Genomic locationchr17 :42148097-42153712
Type of geneprotein-coding
RefGenesNM_138387.3,
NR_028581.1,NR_028582.1,
Ensembl idENSG00000141349
DescriptionG-6-Pase 3G6Pase 3G6Pase-betaglucose-6-phosphatase 3glucose-6-phosphatase catalytic subunit 3ubiquitous glucose-6-phosphatase catalytic subunit-related proteinubiquitously expressed G6Pase catalytic subunit-related protein
Modification date20141207
dbXrefs MIM : 611045
HGNC : HGNC
Ensembl : ENSG00000141349
HPRD : 13556
Vega : OTTHUMG00000181805
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_G6PC3
BioGPS: 92579
Gene Expression Atlas: ENSG00000141349
The Human Protein Atlas: ENSG00000141349
PathwayNCI Pathway Interaction Database: G6PC3
KEGG: G6PC3
REACTOME: G6PC3
ConsensusPathDB
Pathway Commons: G6PC3
MetabolismMetaCyc: G6PC3
HUMANCyc: G6PC3
RegulationEnsembl's Regulation: ENSG00000141349
miRBase: chr17 :42,148,097-42,153,712
TargetScan: NM_138387
cisRED: ENSG00000141349
ContextiHOP: G6PC3
cancer metabolism search in PubMed: G6PC3
UCL Cancer Institute: G6PC3
Assigned class in ccmGDBC

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Phenotypic Information for G6PC3(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: G6PC3
Familial Cancer Database: G6PC3
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: G6PC3
MedGen: G6PC3 (Human Medical Genetics with Condition)
ClinVar: G6PC3
PhenotypeMGI: G6PC3 (International Mouse Phenotyping Consortium)
PhenomicDB: G6PC3

Mutations for G6PC3
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows G6PC3 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BP430643COTL14208168459959084599794G6PC3206333174215342042153547

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=16)
Stat. for Synonymous SNVs
(# total SNVs=9)
Stat. for Deletions
(# total SNVs=3)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr17:42148485-42148485p.R51H2
chr17:42152400-42152400p.S160S2
chr17:42153218-42153218p.K283R2
chr17:42153276-42153276p.P304fs*202
chr17:42148343-42148343p.T4A1
chr17:42152386-42152386p.A156T1
chr17:42153097-42153097p.V243M1
chr17:42152387-42152387p.A156V1
chr17:42153128-42153128p.R253H1
chr17:42148497-42148497p.I55T1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample   41 2 1  1 2   1 1
# mutation   41 2 1  1 2   1 1
nonsynonymous SNV   11 2    1     1 1
synonymous SNV   3    1    2      
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr17:42148497p.E65E1
chr17:42153206p.G107G1
chr17:42148528p.R140S1
chr17:42153250p.R140R1
chr17:42151630p.A156T1
chr17:42153355p.G183G1
chr17:42152338p.L185L1
chr17:42152340p.L185L1
chr17:42152386p.L230P1
chr17:42152691p.V243M1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for G6PC3 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for G6PC3

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AARSD1,ACBD4,C12orf10,CCDC103,COA3,CDKN2AIPNL,CHCHD5,
COASY,EIF4EBP3,FAM134C,G6PC3,GAMT,GHDC,HAGH,
HEXIM2,MDP1,NDUFA2,SLC25A39,TEX264,TMUB2,VPS25
ALG3,APOA1BP,ARF1,ATOX1,C1orf122,C6orf226,CAPNS1,
CFL1,G6PC3,LHPP,MPDU1,ORMDL2,RHBDD2,RHOC,
SEC61B,SERF2,SLC39A3,TAF10,TMEM147,YIF1A,ZDHHC24

AARSD1,ATP5G1,OXLD1,COA3,DCAKD,EFTUD2,ERAL1,
G6PC3,GPS1,MRM1,MRPL10,NME1,NME2,PHB,
PNPO,POLDIP2,PSME3,SLC25A39,SNF8,TMEM199,VPS25
ALDH1B1,EBNA1BP2,ECE2,EIF3I,ERAL1,EEF2KMT,G6PC3,
GADD45GIP1,GCDH,IFRD2,MMAB,MRPL17,MRPL36,NDUFS8,
NOP56,PYCRL,RPF2,TIMM44,TIMM50,TMEM147,TSFM
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for G6PC3


There's no related Drug.
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Cross referenced IDs for G6PC3
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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