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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MAPKAPK2 |
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Phenotypic Information for MAPKAPK2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: MAPKAPK2 |
Familial Cancer Database: MAPKAPK2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
Mutations for MAPKAPK2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | MAPKAPK2 | chr1 | 206897054 | 206897074 | MAPKAPK2 | chr1 | 206868810 | 206868830 |
pancreas | MAPKAPK2 | chr1 | 206872685 | 206872705 | CR1 | chr1 | 207695070 | 207695090 |
pancreas | MAPKAPK2 | chr1 | 206903328 | 206903348 | DUS2L | chr16 | 68098397 | 68098417 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAPKAPK2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=26) | (# total SNVs=7) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:206905967-206905967 | p.Q369Q | 3 |
chr1:206903395-206903395 | p.T215P | 2 |
chr1:206858758-206858758 | p.D62Y | 2 |
chr1:206902418-206902418 | p.R153Q | 2 |
chr1:206904055-206904055 | p.E238D | 2 |
chr1:206902749-206902749 | p.E165K | 2 |
chr1:206902080-206902080 | p.R102H | 2 |
chr1:206904486-206904486 | p.L257L | 1 |
chr1:206902126-206902126 | p.I117I | 1 |
chr1:206905225-206905225 | p.R340R | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 5 | 1 |   |   |   | 1 |   |   | 2 | 2 |   |   |   | 6 | 1 |   | 6 |
# mutation | 2 | 1 |   | 5 | 1 |   |   |   | 1 |   |   | 3 | 3 |   |   |   | 6 | 1 |   | 6 |
nonsynonymous SNV | 1 |   |   | 4 | 1 |   |   |   | 1 |   |   | 3 | 2 |   |   |   | 3 | 1 |   | 6 |
synonymous SNV | 1 | 1 |   | 1 |   |   |   |   |   |   |   |   | 1 |   |   |   | 3 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:206904055 | p.E238E,MAPKAPK2 | 2 |
chr1:206902762 | p.L95R,MAPKAPK2 | 1 |
chr1:206905036 | p.R102H,MAPKAPK2 | 1 |
chr1:206902763 | p.L257L,MAPKAPK2 | 1 |
chr1:206905044 | p.I117I,MAPKAPK2 | 1 |
chr1:206902059 | p.P273L,MAPKAPK2 | 1 |
chr1:206902780 | p.I120I,MAPKAPK2 | 1 |
chr1:206905225 | p.R278C,MAPKAPK2 | 1 |
chr1:206902080 | p.D122Y,MAPKAPK2 | 1 |
chr1:206902809 | p.T315N,MAPKAPK2 | 1 |
Other DBs for Point Mutations |
Copy Number for MAPKAPK2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MAPKAPK2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ADIPOR1,ARF1,ARL8A,C1orf56,C9orf116,DYRK3,FAM63A, IL20,KIAA1377,MAPKAPK2,NIT1,P4HTM,PPP2R5A,PSEN2, PYCR2,RNF187,RNPEP,LAMTOR2,SCN1B,SPR,TMEM9 | ABCF1,ABCF2,AIMP2,ATG4D,ENDOG,ENSA,IER5, MAP2K3,MAPKAPK2,NTMT1,MRPL14,PCBP4,PGP,PKM, PPM1J,PPP1R3F,PRMT1,PTGES2,RBM38,TIMM17B,ZNF672 | ||||
ARL8A,CDC42BPA,CRTC2,DSTYK,DYRK3,GATAD2B,ITPKB, MAPKAPK2,MEF2D,PDE4DIP,PI4KB,SH3BP5L,SHC1,SLC25A44, SLC41A1,SRGAP2,STX6,TP53BP2,UBE2Q1,WDR26,YY1AP1 | ACTG1,AXIN1,BCAR1,CHPF2,CORO7,CTBP1,ELL, FAM83H,FRMD8,GATAD2A,KLF16,MAP2K3,MAPKAPK2,NACC1, P2RY11,PRKD2,SH2B2,SP2,STK10,TRIM26,ZNF598 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for MAPKAPK2 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | P49137; -. |
Chemistry | ChEMBL | CHEMBL2208; -. |
Chemistry | GuidetoPHARMACOLOGY | 2094; -. |
Organism-specific databases | PharmGKB | PA30631; -. |
Organism-specific databases | CTD | 9261; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02010 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | Staurosporine | ||
DB03431 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | Adenosine-5'-Diphosphate | ||
DB07234 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione | ||
DB07406 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE | ||
DB07430 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one | ||
DB07431 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one | ||
DB07728 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | ||
DB08358 | mitogen-activated protein kinase-activated protein kinase 2 | experimental | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | ||
DB00143 | mitogen-activated protein kinase-activated protein kinase 2 | approved; nutraceutical | Glutathione |
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Cross referenced IDs for MAPKAPK2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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