Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for B3GNT7
Basic gene info.Gene symbolB3GNT7
Gene nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonymsbeta3GnT7
CytomapUCSC genome browser: 2q37.1|2q37.1
Genomic locationchr2 :232260334-232265875
Type of geneprotein-coding
RefGenesNM_145236.2,
Ensembl idENSG00000156966
DescriptionBGnT-7beta 1,3-N-acetylglucosaminyltransferase 7beta-1,3-Gn-T7beta-1,3-N-acetylglucosaminyltransferase 7beta3Gn-T7
Modification date20141207
dbXrefs MIM : 615313
HGNC : HGNC
Ensembl : ENSG00000156966
HPRD : 12512
Vega : OTTHUMG00000153880
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_B3GNT7
BioGPS: 93010
Gene Expression Atlas: ENSG00000156966
The Human Protein Atlas: ENSG00000156966
PathwayNCI Pathway Interaction Database: B3GNT7
KEGG: B3GNT7
REACTOME: B3GNT7
ConsensusPathDB
Pathway Commons: B3GNT7
MetabolismMetaCyc: B3GNT7
HUMANCyc: B3GNT7
RegulationEnsembl's Regulation: ENSG00000156966
miRBase: chr2 :232,260,334-232,265,875
TargetScan: NM_145236
cisRED: ENSG00000156966
ContextiHOP: B3GNT7
cancer metabolism search in PubMed: B3GNT7
UCL Cancer Institute: B3GNT7
Assigned class in ccmGDBC

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Phenotypic Information for B3GNT7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: B3GNT7
Familial Cancer Database: B3GNT7
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS
REACTOME_METABOLISM_OF_CARBOHYDRATES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: B3GNT7
MedGen: B3GNT7 (Human Medical Genetics with Condition)
ClinVar: B3GNT7
PhenotypeMGI: B3GNT7 (International Mouse Phenotyping Consortium)
PhenomicDB: B3GNT7

Mutations for B3GNT7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows B3GNT7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=28)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:232263034-232263034p.D202N3
chr2:232262941-232262941p.V171M2
chr2:232262502-232262502p.V24V2
chr2:232263022-232263022p.R198C2
chr2:232263024-232263024p.R198R2
chr2:232263248-232263248p.R273L2
chr2:232262827-232262827p.D133N2
chr2:232263303-232263303p.K291N2
chr2:232263129-232263129p.V233V2
chr2:232262452-232262452p.V8I1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11 91 3 1  22   78 8
# mutation11 101 3 1  22   68 10
nonsynonymous SNV11 91 1 1  12   45 3
synonymous SNV   1  2    1    23 7
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:232263129p.A70S2
chr2:232262827p.V233V2
chr2:232263248p.R273L2
chr2:232262638p.D133N2
chr2:232262452p.R10W1
chr2:232263347p.Y200Y1
chr2:232262809p.S308S1
chr2:232262458p.S28S1
chr2:232263354p.G201G1
chr2:232262811p.D318N1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for B3GNT7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for B3GNT7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

B3GNT3,B3GNT7,NCMAP,BPIFB3,CPVL,F5,FRMD5,
KCNG1,KIAA1644,MAP2,MFGE8,PADI2,PDIA2,RLBP1,
SKI,SLC15A1,SMR3A,SMR3B,SOX6,TPK1,TRPV4
B3GNT7,CYP2A13,DCAF12L2,ERBB2,GAL3ST2,HOXB13,KRT77,
LINC01105,LOC400940,LRRC59,PGAP3,PTPRN2,PVALB,S100A7,
S100A7A,S100P,STARD3,TMEM132A,TUBA1B,TUBB3,UBE2Z

ADAM3A,ASPG,ATP2A3,B3GNT7,B3GALT5-AS1,CA2,CA4,
CDKN2B-AS1,CLDN8,GUCA2A,MS4A12,NPY2R,PLAC8,PYY,
RAB27A,SEPP1,SLC4A4,SLC6A19,TMIGD1,TRIM40,VSTM2A
B3GNT7,PRAC2,B3GALT5-AS1,CLDN8,CPA6,CRYBA2,CT62,
FBXO25,FOXA2,HOXB13,IGSF5,KLRG2,LOC284578,MFSD4,
NEBL,NRAP,SLC2A10,SPON1,ST6GALNAC6,TGM3,WFDC2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for B3GNT7


There's no related Drug.
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Cross referenced IDs for B3GNT7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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