Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for NDST3

Basic gene info.	Gene symbol	NDST3
	Gene name	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
	Synonyms	HSST3
	Cytomap	UCSC genome browser: 4q26
	Genomic location	chr4 :118955499-119179789
	Type of gene	protein-coding
	RefGenes	NM_004784.2,
	Ensembl id	ENSG00000164100
	Description	GlcNAc N-deacetylase/ N-sulfotransferase 3N-HSST 3N-heparan sulfate sulfotransferase 3NDST-3bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3glucosaminyl N-deacetylase/N-sulfotransferase 3hNDST-3
	Modification date	20141207
dbXrefs	MIM : 603950
	HGNC : HGNC
	Ensembl : ENSG00000164100
	Vega : OTTHUMG00000132959
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NDST3
	BioGPS: 9348
	Gene Expression Atlas: ENSG00000164100
	The Human Protein Atlas: ENSG00000164100
Pathway	NCI Pathway Interaction Database: NDST3
	KEGG: NDST3
	REACTOME: NDST3
	ConsensusPathDB
	Pathway Commons: NDST3
Metabolism	MetaCyc: NDST3
	HUMANCyc: NDST3
Regulation	Ensembl's Regulation: ENSG00000164100
	miRBase: chr4 :118,955,499-119,179,789
	TargetScan: NM_004784
	cisRED: ENSG00000164100
Context	iHOP: NDST3
	cancer metabolism search in PubMed: NDST3
	UCL Cancer Institute: NDST3
Assigned class in ccmGDB	C

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Phenotypic Information for NDST3(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: NDST3
	Familial Cancer Database: NDST3

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES

Others
OMIM
Orphanet
Disease	KEGG Disease: NDST3
	MedGen: NDST3 (Human Medical Genetics with Condition)
	ClinVar: NDST3
Phenotype	MGI: NDST3 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: NDST3

Mutations for NDST3

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
breast	NDST3	chr4	119006912	119006912		chr20	7323362	7323362
breast	NDST3	chr4	119006912	119006912	NDST3	chr4	119012493	119012493
ovary	NDST3	chr4	119055224	119055244	NDST3	chr4	119051288	119051308
pancreas	NDST3	chr4	119147667	119147687		chr4	178214553	178214573

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NDST3 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

AV697913

RPS6

151

296

19376253

19376507

NDST3

287

310

118999891

118999914

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=87)	Stat. for Synonymous SNVs (# total SNVs=24)

Stat. for Deletions (# total SNVs=2)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr4:119161842-119161842	p.P761L	3
chr4:118975673-118975673	p.R203H	3
chr4:119059310-119059310	p.W442C	3
chr4:118976014-118976014	p.E317K	3
chr4:118975397-118975397	p.A111V	3
chr4:118975856-118975856	p.H264R	3
chr4:119161837-119161837	p.P761fs*5	2
chr4:118975857-118975857	p.H264Q	2
chr4:119154278-119154278	p.R644M	2
chr4:119036052-119036052	p.P387P	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2	3	1	18	2		5		4			12	5		1	1	23	14	1	10
# mutation	2	3	1	16	2		6		4			12	5		1	1	25	15	1	15
nonsynonymous SNV	2	1	1	14	1		3		1			8	4		1		20	10	1	14
synonymous SNV		2		2	1		3		3			4	1			1	5	5		1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr4:118975856	p.V427I	3
chr4:119059263	p.H264R	3
chr4:119148127	p.P241T	2
chr4:119154231	p.S245Y	2
chr4:119059259	p.P603P	2
chr4:118975786	p.P628P	2
chr4:118975799	p.R203H	2
chr4:118975673	p.S425S	2
chr4:118975835	p.V757A	1
chr4:119064714	p.R147Q	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for NDST3 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for NDST3

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AFF2,C17orf51,CHRNA3,GABRG2,KCNK10,LOC100133545,MET, MMP26,NDST3,NTS,P2RX6,PCSK1,PDGFRA,PRMT8, PTPRN,PTX3,RASSF9,SLC10A4,TMEFF2,TNMD,VGF	ACTBL2,CA13,CBLN4,CHN1,CLDN1,DEFB131,FAM133A, FAM3C,KCNK2,LXN,MAPK1IP1L,NDST3,NDST4,NUS1, OR6Y1,RGS2,SLC26A2,SOCS5,STXBP3,TBK1,UBLCP1

CH25H,COL9A1,CORIN,DKK3,F2R,F2RL2,FAT4, FIBIN,FOXF1,GLI1,GPR1,IP6K3,ITGA11,KLHL13, NDST3,PCDH18,PDGFC,PDZD2,SDC2,TNFSF11,WNT2	ADORA2B,ALDH3A1,ARL15,CNTN4,EFNB2,EPB41L5,BRINP2, HAS3,LANCL3,LOC723809,MIER3,NDST3,NFE2L2,NPHS2, NRG1,RPL10L,SLC20A1,UGDH,UGT1A10,UGT1A8,ZNF800

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for NDST3

There's no related Drug.

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Cross referenced IDs for NDST3

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information