Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for HS6ST1

Basic gene info.	Gene symbol	HS6ST1
	Gene name	heparan sulfate 6-O-sulfotransferase 1
	Synonyms	HH15\|HS6ST
	Cytomap	UCSC genome browser: 2q21
	Genomic location	chr2 :129023053-129076171
	Type of gene	protein-coding
	RefGenes	NM_004807.2,
	Ensembl id	ENSG00000136720
	Description	HS6ST-1heparan-sulfate 6-O-sulfotransferase 1heparan-sulfate 6-sulfotransferase
	Modification date	20141207
dbXrefs	MIM : 604846
	HGNC : HGNC
	Ensembl : ENSG00000136720
	HPRD : 07274
	Vega : OTTHUMG00000153542
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HS6ST1
	BioGPS: 9394
	Gene Expression Atlas: ENSG00000136720
	The Human Protein Atlas: ENSG00000136720
Pathway	NCI Pathway Interaction Database: HS6ST1
	KEGG: HS6ST1
	REACTOME: HS6ST1
	ConsensusPathDB
	Pathway Commons: HS6ST1
Metabolism	MetaCyc: HS6ST1
	HUMANCyc: HS6ST1
Regulation	Ensembl's Regulation: ENSG00000136720
	miRBase: chr2 :129,023,053-129,076,171
	TargetScan: NM_004807
	cisRED: ENSG00000136720
Context	iHOP: HS6ST1
	cancer metabolism search in PubMed: HS6ST1
	UCL Cancer Institute: HS6ST1
Assigned class in ccmGDB	C

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Phenotypic Information for HS6ST1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: HS6ST1
	Familial Cancer Database: HS6ST1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_CARBOHYDRATES

Others
OMIM
Orphanet
Disease	KEGG Disease: HS6ST1
	MedGen: HS6ST1 (Human Medical Genetics with Condition)
	ClinVar: HS6ST1
Phenotype	MGI: HS6ST1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: HS6ST1

Mutations for HS6ST1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
breast	HS6ST1	chr2	129028833	129028833		chr2	129182142	129182142
ovary	HS6ST1	chr2	129056092	129056112	HS6ST1	chr2	129064226	129064246

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HS6ST1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

BQ375227

PEBP1

118577253

118577336

HS6ST1

356

129023995

129024269

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=9

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=46)	Stat. for Synonymous SNVs (# total SNVs=9)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr2:129075877-129075877	p.D87E	9
chr2:129025860-129025860	p.R371H	8
chr2:129026227-129026227	p.R249S	6
chr2:129075797-129075797	p.V114G	4
chr2:129075961-129075961	p.T59T	4
chr2:129026419-129026419	p.R185*	4
chr2:129026421-129026421	p.L184P	4
chr2:129025928-129025928	p.Y348Y	3
chr2:129075939-129075939	p.K67*	3
chr2:129025758-129025758	p.S405I	3

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	5		2			2					3	3				3	5		7
# mutation	1	2		2			2					3	3				2	5		6
nonsynonymous SNV	1	2		2			1					3	3				1	2		3
synonymous SNV							1										1	3		3

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr2:129075877	p.D87E	4
chr2:129026218	p.R252C	2
chr2:129026412	p.T228T	2
chr2:129026288	p.R371H	2
chr2:129025860	p.P187R	2
chr2:129025925	p.N341N	1
chr2:129026332	p.I181I	1
chr2:129025948	p.Q318R	1
chr2:129026338	p.F308L	1
chr2:129025949	p.P269P	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for HS6ST1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HS6ST1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AAMP,ABHD8,AGAP3,BAG1,DNAJB2,DVL1,ERCC3, GRAMD4,HS6ST1,IMP4,MTCL1,NACC1,NSMF,OBSL1, POMGNT1,SLC4A3,SMPD4,STK25,THAP4,TMEM177,WDR33	AGRN,ARVCF,CADM4,CAPN1,CHST10,EPS8L2,EVPL, FAM129B,FBXL19,H2AFY2,HS6ST1,ITGB4,LSR,NGFR, NKD2,PKP3,RTKN,SEPT9,SMARCA4,ST14,U2AF2

ASXL1,CEP250,CLASP1,DNAJC5,ELMO2,FMNL2,HS6ST1, LRP3,LSM14B,MYO7A,NCOA6,NOD2,OGFR,PLCG1, SLC5A6,SNRNP200,SNX21,TAF4,UGGT1,ZGPAT,ZNF319	ARHGAP17,ATG2A,CACFD1,CLCN2,CLDN4,CLSTN1,CYTH2, GBA,GBAP1,GMIP,HS6ST1,JUP,LRP10,MARK2, NR2F6,OSBPL2,PCSK7,SLC9A1,TMEM127,TMEM8A,WWP2

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HS6ST1

There's no related Drug.

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Cross referenced IDs for HS6ST1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information