Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ABCG2
Basic gene info.Gene symbolABCG2
Gene nameATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
SynonymsABC15|ABCP|BCRP|BCRP1|BMDP|CD338|CDw338|EST157481|GOUT1|MRX|MXR|MXR1|UAQTL1
CytomapUCSC genome browser: 4q22
Genomic locationchr4 :89011415-89152474
Type of geneprotein-coding
RefGenesNM_001257386.1,
NM_004827.2,
Ensembl idENSG00000118777
DescriptionABC transporterATP-binding cassette sub-family G member 2ATP-binding cassette transporter G2breast cancer resistance proteinmitoxantrone resistance-associated proteinmulti drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) mem
Modification date20141222
dbXrefs MIM : 603756
HGNC : HGNC
Ensembl : ENSG00000118777
HPRD : 04783
Vega : OTTHUMG00000130601
ProteinUniProt: Q9UNQ0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ABCG2
BioGPS: 9429
Gene Expression Atlas: ENSG00000118777
The Human Protein Atlas: ENSG00000118777
PathwayNCI Pathway Interaction Database: ABCG2
KEGG: ABCG2
REACTOME: ABCG2
ConsensusPathDB
Pathway Commons: ABCG2
MetabolismMetaCyc: ABCG2
HUMANCyc: ABCG2
RegulationEnsembl's Regulation: ENSG00000118777
miRBase: chr4 :89,011,415-89,152,474
TargetScan: NM_001257386
cisRED: ENSG00000118777
ContextiHOP: ABCG2
cancer metabolism search in PubMed: ABCG2
UCL Cancer Institute: ABCG2
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ABCG2 in cancer cell metabolism1. Jung KA, Choi BH, Kwak MK (2015) The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression. Mol Pharmacol 87: 465-476. doi: 10.1124/mol.114.096065. go to article
2. Rao DK, Liu H, Ambudkar SV, Mayer M (2014) A combination of curcumin with either gramicidin or ouabain selectively kills cells that express the multidrug resistance-linked ABCG2 transporter. J Biol Chem 289: 31397-31410. doi: 10.1074/jbc.M114.576819. pmid: 4223339. go to article
3. Wu Y, Si R, Tang H, He Z, Zhu H, et al. (2015) Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma. Biochem Biophys Res Commun 457: 614-620. doi: 10.1016/j.bbrc.2015.01.035. go to article

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Phenotypic Information for ABCG2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ABCG2
Familial Cancer Database: ABCG2
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM

check002.gifOthers
OMIM 138900; phenotype.
138900; phenotype.
603756; gene.
603756; gene.
614490; phenotype.
614490; phenotype.
Orphanet
DiseaseKEGG Disease: ABCG2
MedGen: ABCG2 (Human Medical Genetics with Condition)
ClinVar: ABCG2
PhenotypeMGI: ABCG2 (International Mouse Phenotyping Consortium)
PhenomicDB: ABCG2

Mutations for ABCG2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryABCG2chr48908331389083333HERC5chr48940889189408911
ovaryABCG2chr48914029189140311ABCG2chr48914222189142241
pancreasABCG2chr48905068189050701PCGF3chr4702315702335
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ABCG2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AA001604ZKSCAN1122979962984899630076ABCG222542148907242989072623

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample1  1             
GAIN (# sample)1                
LOSS (# sample)   1             
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=74)
Stat. for Synonymous SNVs
(# total SNVs=18)
Stat. for Deletions
(# total SNVs=4)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:89052323-89052323p.Q141K3
chr4:89042907-89042907p.E190G3
chr4:89061129-89061129p.E7K2
chr4:89039317-89039317p.G262E2
chr4:89042908-89042908p.E190*2
chr4:89060991-89060991p.L53V2
chr4:89052286-89052286p.T153M2
chr4:89028360-89028360p.N418I2
chr4:89034590-89034590p.S353S2
chr4:89018639-89018639p.T538R2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 143 3 23 153   97 15
# mutation 1 143 3 23 143   117 20
nonsynonymous SNV   102 2 22 92   74 15
synonymous SNV 1 41 1  1 51   43 5
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:89042907p.E190G,ABCG23
chr4:89034590p.G354W,ABCG22
chr4:89013497p.S353S,ABCG22
chr4:89034589p.I619I2
chr4:89022469p.K172Q,ABCG21
chr4:89052313p.I108V,ABCG21
chr4:89060953p.G618S1
chr4:89016750p.V404I,ABCG21
chr4:89039279p.E285K,ABCG21
chr4:89028360p.G281G,ABCG21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ABCG2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ABCG2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABCB1,ABCG2,APOD,ART1,CASP14,CCDC152,CHRNA10,
EGLN3,ENTHD1,FUT11,GSTM1,HERC4,KCNK12,LOC731779,
MCHR1,MYPN,PCDH7,SEPP1,SLC10A1,SLC1A7,ZNF175
ABCG2,ANKRD13A,ANXA8,ARHGEF9,ATP6V1B1,C22orf42,CCL28,
ETV6,FAM81A,FOXI1,IQCF5,ITPRIPL1,KIAA1671,KIT,
LOXL4,NAV2,PLA2R1,RSPO1,SH3RF2,SLC6A14,TRIM60

ABCG2,ALPI,C11orf86,LINC00520,C1orf94,CAPN11,CDHR2,
CIDEC,CLDN23,DHRS9,FAM25BP,GDPD2,GLRA4,GUCA2B,
MYPN,TM6SF2,TRANK1,UGT1A1,UGT1A4,UGT1A5,VSIG1
ABCG2,ARL4A,SH3D21,CDC14A,FLVCR2,GCOM1,GLS,
MAP3K2,MIA2,MT1DP,PDXP,PRKG2,RHOU,SLC1A1,
SLC26A1,SLC3A1,SULT1A2,SLC35G1,TRPV3,UGT1A1,UGT1A9
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ABCG2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB Q9UNQ0; -.
ChemistryChEMBL CHEMBL5393; -.
ChemistryBindingDB Q9UNQ0; -.
ChemistryChEMBL CHEMBL5393; -.
Organism-specific databasesPharmGKB PA390; -.
Organism-specific databasesPharmGKB PA390; -.
Organism-specific databasesCTD 9429; -.
Organism-specific databasesCTD 9429; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00709ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalLamivudine
DB00390ATP-binding cassette, sub-family G (WHITE), member 2approvedDigoxin
DB00997ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalDoxorubicin
DB00987ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalCytarabine
DB00694ATP-binding cassette, sub-family G (WHITE), member 2approvedDaunorubicin
DB00773ATP-binding cassette, sub-family G (WHITE), member 2approvedEtoposide
DB01204ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalMitoxantrone
DB00541ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalVincristine
DB00313ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalValproic Acid
DB00544ATP-binding cassette, sub-family G (WHITE), member 2approvedFluorouracil
DB00495ATP-binding cassette, sub-family G (WHITE), member 2approvedZidovudine
DB01095ATP-binding cassette, sub-family G (WHITE), member 2approvedFluvastatin
DB00641ATP-binding cassette, sub-family G (WHITE), member 2approvedSimvastatin
DB00958ATP-binding cassette, sub-family G (WHITE), member 2approvedCarboplatin
DB01076ATP-binding cassette, sub-family G (WHITE), member 2approvedAtorvastatin
DB01098ATP-binding cassette, sub-family G (WHITE), member 2approvedRosuvastatin
DB00441ATP-binding cassette, sub-family G (WHITE), member 2approvedGemcitabine
DB00563ATP-binding cassette, sub-family G (WHITE), member 2approvedMethotrexate
DB01196ATP-binding cassette, sub-family G (WHITE), member 2approvedEstramustine
DB00361ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalVinorelbine
DB00619ATP-binding cassette, sub-family G (WHITE), member 2approvedImatinib
DB00158ATP-binding cassette, sub-family G (WHITE), member 2approved; nutraceuticalFolic Acid
DB00650ATP-binding cassette, sub-family G (WHITE), member 2approvedLeucovorin
DB00317ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalGefitinib
DB00530ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalErlotinib
DB00795ATP-binding cassette, sub-family G (WHITE), member 2approvedSulfasalazine
DB00515ATP-binding cassette, sub-family G (WHITE), member 2approvedCisplatin
DB01030ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalTopotecan
DB00175ATP-binding cassette, sub-family G (WHITE), member 2approvedPravastatin
DB00531ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalCyclophosphamide
DB01229ATP-binding cassette, sub-family G (WHITE), member 2approvedPaclitaxel
DB00877ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalSirolimus
DB00864ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalTacrolimus
DB00564ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalCarbamazepine
DB00762ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalIrinotecan
DB01248ATP-binding cassette, sub-family G (WHITE), member 2approved; investigationalDocetaxel
DB01016ATP-binding cassette, sub-family G (WHITE), member 2approvedGlyburide
DB00331ATP-binding cassette, sub-family G (WHITE), member 2approvedMetformin


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Cross referenced IDs for ABCG2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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