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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MED7 |
Basic gene info. | Gene symbol | MED7 |
Gene name | mediator complex subunit 7 | |
Synonyms | ARC34|CRSP33|CRSP9 | |
Cytomap | UCSC genome browser: 5q33.3 | |
Genomic location | chr5 :156565450-156569921 | |
Type of gene | protein-coding | |
RefGenes | NM_001100816.1, NM_004270.4, | |
Ensembl id | ENSG00000155868 | |
Description | CRSP complex subunit 9RNA polymerase transcriptional regulation mediator subunit 7 homologactivator-recruited cofactor 34 kDa componentcofactor required for Sp1 transcriptional activation subunit 9cofactor required for Sp1 transcriptional activation, | |
Modification date | 20141207 | |
dbXrefs | MIM : 605045 | |
HGNC : HGNC | ||
Ensembl : ENSG00000155868 | ||
HPRD : 05439 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MED7 | |
BioGPS: 9443 | ||
Gene Expression Atlas: ENSG00000155868 | ||
The Human Protein Atlas: ENSG00000155868 | ||
Pathway | NCI Pathway Interaction Database: MED7 | |
KEGG: MED7 | ||
REACTOME: MED7 | ||
ConsensusPathDB | ||
Pathway Commons: MED7 | ||
Metabolism | MetaCyc: MED7 | |
HUMANCyc: MED7 | ||
Regulation | Ensembl's Regulation: ENSG00000155868 | |
miRBase: chr5 :156,565,450-156,569,921 | ||
TargetScan: NM_001100816 | ||
cisRED: ENSG00000155868 | ||
Context | iHOP: MED7 | |
cancer metabolism search in PubMed: MED7 | ||
UCL Cancer Institute: MED7 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for MED7(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: MED7 |
Familial Cancer Database: MED7 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: MED7 |
MedGen: MED7 (Human Medical Genetics with Condition) | |
ClinVar: MED7 | |
Phenotype | MGI: MED7 (International Mouse Phenotyping Consortium) |
PhenomicDB: MED7 |
Mutations for MED7 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MED7 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=3) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:156565983-156565983 | p.Q154* | 2 |
chr5:156566273-156566273 | p.R57H | 2 |
chr5:156565803-156565803 | p.Q214E | 1 |
chr5:156566122-156566122 | p.E107D | 1 |
chr5:156566369-156566369 | p.N25S | 1 |
chr5:156565862-156565862 | p.S194I | 1 |
chr5:156566142-156566142 | p.G101W | 1 |
chr5:156566386-156566386 | p.K19N | 1 |
chr5:156565878-156565878 | p.M189V | 1 |
chr5:156566145-156566145 | p.P100T | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 1 | 3 |   | 1 |   | 1 | 1 |   | 5 | 2 |   |   |   | 2 | 2 |   | 5 |
# mutation | 1 | 1 |   | 1 | 3 |   | 1 |   | 1 | 1 |   | 5 | 2 |   |   |   | 2 | 2 |   | 5 |
nonsynonymous SNV | 1 | 1 |   | 1 | 3 |   | 1 |   | 1 | 1 |   | 3 | 2 |   |   |   | 1 | 2 |   | 3 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   | 2 |   |   |   |   | 1 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:156565803 | p.S194I,MED7 | 1 |
chr5:156566061 | p.R57P,MED7 | 1 |
chr5:156566373 | p.M189L,MED7 | 1 |
chr5:156565837 | p.G29C,MED7 | 1 |
chr5:156566062 | p.T186P,MED7 | 1 |
chr5:156566376 | p.Q27H,MED7 | 1 |
chr5:156565862 | p.E179Q,MED7 | 1 |
chr5:156566122 | p.N25S,MED7 | 1 |
chr5:156566386 | p.S178S,MED7 | 1 |
chr5:156565878 | p.E24K,MED7 | 1 |
Other DBs for Point Mutations |
Copy Number for MED7 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MED7 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
CAMLG,CCNH,CETN3,COMMD10,COX7C,FAM114A2,GIN1, MED7,MRPL22,MRPS36,NDFIP1,NDUFA2,PFDN1,POC5, PPP2CA,RBM22,SKP1,TAF9,TIGD6,TTC1,ZCCHC10 | ACTR10,ANAPC13,ATP8B5P,BCAS2,C18orf32,C4orf27,CGRRF1, GTF2A2,HMGB1,IER3IP1,MED4,MED7,PIGF,RPP30, RPS27L,SELT,SUMO1,TAF9,TMEM50B,UBE2D2,ZCCHC9 |
ATP5L,ATP6V0E1,TRAPPC13,CCNH,CETN3,COX7C,HINT1, MED7,MRPL22,MRPS36,NDUFA2,NDUFS4,PFDN1,TAF9, TBCA,TTC1,UBE2B,UBE2D2,UQCRQ,ZCCHC10,ZCCHC9 | ATG5,C18orf32,C1D,METTL18,CDC42,CNIH4,FAM103A1, GABARAPL2,LAMTOR3,MED4,MED7,ORC4,RNF14,SCOC, SRP9,TAF7,TMBIM4,TMEM106B,TTC1,UBE2B,ZFAND6 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for MED7 |
There's no related Drug. |
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Cross referenced IDs for MED7 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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