Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for GSTO1

Basic gene info.	Gene symbol	GSTO1
	Gene name	glutathione S-transferase omega 1
	Synonyms	GSTO 1-1\|GSTTLp28\|HEL-S-21\|P28\|SPG-R
	Cytomap	UCSC genome browser: 10q25.1
	Genomic location	chr10 :106013951-106027222
	Type of gene	protein-coding
	RefGenes	NM_001191002.1, NM_001191003.1,NM_004832.2,
	Ensembl id	ENSG00000148834
	Description	GSTO-1MMA(V) reductaseS-(Phenacyl)glutathione reductaseepididymis secretory protein Li 21glutathione S-transferase omega 1-1glutathione S-transferase omega-1glutathione-S-transferase likeglutathione-dependent dehydroascorbate reductasemonomethylar
	Modification date	20141207
dbXrefs	MIM : 605482
	HGNC : HGNC
	Ensembl : ENSG00000148834
	HPRD : 10401
	Vega : OTTHUMG00000019001
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GSTO1
	BioGPS: 9446
	Gene Expression Atlas: ENSG00000148834
	The Human Protein Atlas: ENSG00000148834
Pathway	NCI Pathway Interaction Database: GSTO1
	KEGG: GSTO1
	REACTOME: GSTO1
	ConsensusPathDB
	Pathway Commons: GSTO1
Metabolism	MetaCyc: GSTO1
	HUMANCyc: GSTO1
Regulation	Ensembl's Regulation: ENSG00000148834
	miRBase: chr10 :106,013,951-106,027,222
	TargetScan: NM_001191002
	cisRED: ENSG00000148834
Context	iHOP: GSTO1
	cancer metabolism search in PubMed: GSTO1
	UCL Cancer Institute: GSTO1
Assigned class in ccmGDB	C

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Phenotypic Information for GSTO1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: GSTO1
	Familial Cancer Database: GSTO1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

Others
OMIM
Orphanet
Disease	KEGG Disease: GSTO1
	MedGen: GSTO1 (Human Medical Genetics with Condition)
	ClinVar: GSTO1
Phenotype	MGI: GSTO1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: GSTO1

Mutations for GSTO1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTO1 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AA234313	CPD	1	140	17	28758847	28766081	GSTO1	131	383	10	106019490	106025928
BG314836	GSTO1	6	183	10	106014951	106019431	PLIN2	175	556	9	19115888	19116268
BC082963	HS3ST3A1	22	2058	17	13399487	13505235	GSTO1	2058	2858	10	106014662	106027213

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=8)	Stat. for Synonymous SNVs (# total SNVs=2)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr10:106022834-106022836	p.?	3
chr10:106022789-106022789	p.A140D	1
chr10:106022834-106022834	p.E155V	1
chr10:106014943-106014943	p.V19V	1
chr10:106025846-106025846	p.L157P	1
chr10:106014984-106014984	p.P33L	1
chr10:106025851-106025851	p.N159D	1
chr10:106015023-106015023	p.G46E	1
chr10:106025864-106025864	p.T163I	1
chr10:106019360-106019360	p.K57T	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	1		1			3						1				2			3
# mutation	1	1		1			3						1				2			3
nonsynonymous SNV	1			1			2						1				2			3
synonymous SNV		1					1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr10:106025846	p.D176N,GSTO1	1
chr10:106025864	p.V19V,GSTO1	1
chr10:106027036	p.P20P,GSTO1	1
chr10:106014943	p.P33L,GSTO1	1
chr10:106027062	p.K57T,GSTO1	1
chr10:106014946	p.G80S,GSTO1	1
chr10:106014984	p.E85K,GSTO1	1
chr10:106019360	p.L98F,GSTO1	1
chr10:106019428	p.R104K,GSTO1	1
chr10:106019443	p.L124P,GSTO1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for GSTO1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GSTO1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


BLOC1S1,C19orf43,COX4I1,EDF1,EXOSC1,GADD45GIP1,GPX1, GSTO1,LOC100270710,MRPL23,LINC00152,NDUFA11,NDUFB8,PFDN5, PSMB6,RHOG,RNASEK,RPL24,RPLP2,TNFSF12-TNFSF13,USMG5	ARPC2,ATP6V1F,AKIP1,C17orf49,CAPZB,GABARAP,GSTO1, IFI27L2,JTB,LST1,NENF,NPC2,NUTF2,PFN1, RBX1,RHOG,SCNM1,SH3BGRL3,SNRPG,TMSB10,TRAPPC1

ASNA1,FAM204A,COX7A2,GADD45GIP1,GLRX3,GPX1,GSTO1, LSM2,MED31,MRPL43,MRPL54,MYEOV2,NDUFA11,NDUFA13, NDUFB7,NDUFB8,PFDN5,SNRPG,TIMM8B,TOMM22,VPS29	BET1,COX14,IFT43,CHCHD2,CKLF,DYNLT1,GLO1, GSTO1,IFT20,LSM1,MYEOV2,NDUFB6,POLR2C,PSMA2, PSMA6,PSMA7,PSMB1,PSMB4,PSMD8,PSMD9,RNF181

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GSTO1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00143	glutathione S-transferase omega 1	approved; nutraceutical	Glutathione
DB00515	glutathione S-transferase omega 1	approved	Cisplatin
DB01169	glutathione S-transferase omega 1	approved; investigational	Arsenic trioxide

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Cross referenced IDs for GSTO1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information