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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for AKAP5 |
Basic gene info. | Gene symbol | AKAP5 |
Gene name | A kinase (PRKA) anchor protein 5 | |
Synonyms | AKAP75|AKAP79|H21 | |
Cytomap | UCSC genome browser: 14q23.3 | |
Genomic location | chr14 :64932216-64941221 | |
Type of gene | protein-coding | |
RefGenes | NM_004857.3, | |
Ensembl id | ENSG00000179841 | |
Description | A-kinase anchor protein 5A-kinase anchor protein 79 kDaA-kinase anchoring protein 75/79AKAP 79cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 604688 | |
HGNC : HGNC | ||
Ensembl : ENSG00000179841 | ||
HPRD : 05255 | ||
Vega : OTTHUMG00000029634 | ||
Protein | UniProt: P24588 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AKAP5 | |
BioGPS: 9495 | ||
Gene Expression Atlas: ENSG00000179841 | ||
The Human Protein Atlas: ENSG00000179841 | ||
Pathway | NCI Pathway Interaction Database: AKAP5 | |
KEGG: AKAP5 | ||
REACTOME: AKAP5 | ||
ConsensusPathDB | ||
Pathway Commons: AKAP5 | ||
Metabolism | MetaCyc: AKAP5 | |
HUMANCyc: AKAP5 | ||
Regulation | Ensembl's Regulation: ENSG00000179841 | |
miRBase: chr14 :64,932,216-64,941,221 | ||
TargetScan: NM_004857 | ||
cisRED: ENSG00000179841 | ||
Context | iHOP: AKAP5 | |
cancer metabolism search in PubMed: AKAP5 | ||
UCL Cancer Institute: AKAP5 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for AKAP5(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: AKAP5 |
Familial Cancer Database: AKAP5 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_INTEGRATION_OF_ENERGY_METABOLISM |
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OMIM | 604688; gene. |
Orphanet | |
Disease | KEGG Disease: AKAP5 |
MedGen: AKAP5 (Human Medical Genetics with Condition) | |
ClinVar: AKAP5 | |
Phenotype | MGI: AKAP5 (International Mouse Phenotyping Consortium) |
PhenomicDB: AKAP5 |
Mutations for AKAP5 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKAP5 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=6) |
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(# total SNVs=2) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:64935339-64935339 | p.R76Q | 2 |
chr14:64936052-64936052 | p.E314* | 2 |
chr14:64935947-64935947 | p.E279* | 1 |
chr14:64936355-64936355 | p.M415V | 1 |
chr14:64935619-64935619 | p.L169F | 1 |
chr14:64935965-64935965 | p.L285V | 1 |
chr14:64935155-64935155 | p.E15K | 1 |
chr14:64936385-64936385 | p.L425I | 1 |
chr14:64935662-64935662 | p.E184K | 1 |
chr14:64935975-64935975 | p.A288E | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 3 | 1 |   | 1 |   | 1 |   | 1 | 3 | 1 |   |   |   |   | 3 |   | 4 |
# mutation | 2 |   |   | 3 | 1 |   | 1 |   | 1 |   | 1 | 4 | 1 |   |   |   |   | 3 |   | 4 |
nonsynonymous SNV | 2 |   |   | 2 | 1 |   | 1 |   |   |   | 1 | 2 | 1 |   |   |   |   | 1 |   | 4 |
synonymous SNV |   |   |   | 1 |   |   |   |   | 1 |   |   | 2 |   |   |   |   |   | 2 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:64935787 | p.T225T | 3 |
chr14:64935359 | p.E298E | 1 |
chr14:64935861 | p.E367Q | 1 |
chr14:64935406 | p.K83E | 1 |
chr14:64935965 | p.S397P | 1 |
chr14:64935416 | p.Q98H | 1 |
chr14:64935975 | p.S407P | 1 |
chr14:64935446 | p.E102K | 1 |
chr14:64936006 | p.L411R | 1 |
chr14:64935518 | p.E112K | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for AKAP5 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AKAP5,ALDH6A1,C4orf32,C9orf152,INIP,CCDC126,CD46, EDEM3,EPB41L4A,GPR160,IQGAP2,SEL1L,SLC35A3,SLC44A4, SYNJ2BP,TC2N,TMEM87B,TRAK2,UBR7,ZNF678,ZNF91 | AKAP5,ARSJ,TBC1D32,CCDC125,COL4A5,ENPP5,KIF3A, PRLR,RAB27B,RALGPS1,RCAN3,RPS6KA6,ZNF260,ZNF311, ZNF439,ZNF486,ZNF594,ZNF709,ZNF713,ZNF793,ZNF91 | ||||
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AKAP5,APBA1,ATP2A3,B3GNT6,BCAS1,LINC01550,CYP1B1-AS1, SMIM14,CAPN9,CBFA2T3,FCGBP,GALNT12,GNAQ,GNE, LRRIQ4,MB,NRAP,RNASE4,SPDEF,ST6GALNAC1,ST6GALNAC6 | AKAP5,C9orf152,CMTM8,FAM3D,HEPACAM2,IL1R2,KLK1, LOC728606,MFSD4,MLLT3,NRAP,RAB27A,REP15,SCGB2A1, SLC25A38,ST6GALNAC1,TFF3,TMEM61,TSPAN13,VSIG2,ZG16 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for AKAP5 |
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DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA24669; -. |
Organism-specific databases | CTD | 9495; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00864 | A kinase (PRKA) anchor protein 5 | approved; investigational | Tacrolimus | ![]() | ![]() |
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Cross referenced IDs for AKAP5 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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