Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ENTPD1
Basic gene info.Gene symbolENTPD1
Gene nameectonucleoside triphosphate diphosphohydrolase 1
SynonymsATPDase|CD39|NTPDase-1|SPG64
CytomapUCSC genome browser: 10q24
Genomic locationchr10 :97515672-97637023
Type of geneprotein-coding
RefGenesNM_001098175.1,
NM_001164178.1,NM_001164179.1,NM_001164181.1,NM_001164182.1,
NM_001164183.1,NM_001776.5,
Ensembl idENSG00000138185
DescriptionCD39 antigenNTPDase 1ecto-ATP diphosphohydrolase 1ecto-ATPDase 1ecto-ATPase 1ecto-apyraselymphoid cell activation antigen
Modification date20141222
dbXrefs MIM : 601752
HGNC : HGNC
Ensembl : ENSG00000138185
HPRD : 09047
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENTPD1
BioGPS: 953
Gene Expression Atlas: ENSG00000138185
The Human Protein Atlas: ENSG00000138185
PathwayNCI Pathway Interaction Database: ENTPD1
KEGG: ENTPD1
REACTOME: ENTPD1
ConsensusPathDB
Pathway Commons: ENTPD1
MetabolismMetaCyc: ENTPD1
HUMANCyc: ENTPD1
RegulationEnsembl's Regulation: ENSG00000138185
miRBase: chr10 :97,515,672-97,637,023
TargetScan: NM_001098175
cisRED: ENSG00000138185
ContextiHOP: ENTPD1
cancer metabolism search in PubMed: ENTPD1
UCL Cancer Institute: ENTPD1
Assigned class in ccmGDBC

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Phenotypic Information for ENTPD1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ENTPD1
Familial Cancer Database: ENTPD1
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM
KEGG_PYRIMIDINE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ENTPD1
MedGen: ENTPD1 (Human Medical Genetics with Condition)
ClinVar: ENTPD1
PhenotypeMGI: ENTPD1 (International Mouse Phenotyping Consortium)
PhenomicDB: ENTPD1

Mutations for ENTPD1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
DA313964RTN418625519966755199752ENTPD187550109751592097602224
DR006627PRKACA23456191421757214228556ENTPD1452694109762743997627682
AW581220ENTPD1175109762600297626077ENTPD170277109762605697626263
BF374130ENTPD11198109755289297553089IKZF119332075047062550470752
BE796741ENTPD1102125109748532397485346RPL13120751168962713789628145
AV721912ENTPD128613109759326597633514ENTPD1610719109759436997594478
W80598ENTPD1114133109760291297602931DGKH134418134281178542812066

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=34)
Stat. for Synonymous SNVs
(# total SNVs=9)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr10:97607227-97607227p.D280N2
chr10:97602241-97602241p.R135W2
chr10:97599530-97599530p.G76D2
chr10:97605259-97605259p.R240H2
chr10:97599541-97599541p.Q80*2
chr10:97599558-97599558p.R85R2
chr10:97605318-97605318p.Q260*1
chr10:97599452-97599452p.G50E1
chr10:97607350-97607350p.N321H1
chr10:97602187-97602187p.P117S1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 82 3 1 1521  117 5
# mutation 1 62 3 1 1621  127 5
nonsynonymous SNV 1 4  2   162   105 3
synonymous SNV   22 1 1    1  22 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr10:97605259p.G83D,ENTPD12
chr10:97607227p.R102H,ENTPD12
chr10:97599530p.D142N,ENTPD12
chr10:97605149p.T65T,ENTPD12
chr10:97607421p.T70T,ENTPD11
chr10:97583121p.K230T,ENTPD11
chr10:97602207p.L60L,ENTPD11
chr10:97607463p.G77V,ENTPD11
chr10:97599452p.E242K,ENTPD11
chr10:97602241p.G63G,ENTPD11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ENTPD1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENTPD1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

DCN,ECM2,ELK3,ENTPD1,F2R,FAM26E,FMNL3,
GAS7,HEG1,KCTD12,KIAA1462,OLFML1,PLXNC1,RECK,
PEAK1,SLIT2,TCF4,VCAN,WIPF1,ZEB1,ZEB2
ABCC4,CDH11,CHST15,CNTN4,CYP1B1,DNAJC10,ENTPD1,
F2R,F2RL2,LRRC16A,MICAL2,MXRA5,MYO1E,PLXDC1,
PLXNC1,SEC24D,SERPINE2,STARD4,TLR7,UGGT1,WWC3

VSTM4,C1S,CNRIP1,DZIP1,ENTPD1,FBXL7,FSTL1,
GAS7,GNB4,GUCY1B3,LPHN2,MAF,OLFML1,PABPC5,
PKD2,PTPRM,QKI,SYT11,TCF4,ZEB2,ZNF521
ACTA2,ACTG2,ACTN1,ANXA6,CASQ2,CNN1,CSRP1,
ENTPD1,FHL3,RBFOX3,ILDR2,ILK,ITGB3,LGALS1,
LOC100192378,NLGN1,PDLIM7,TAGLN,TMEM200B,TUBA1A,ZFHX4
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENTPD1


There's no related Drug.
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Cross referenced IDs for ENTPD1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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