Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ENTPD2
Basic gene info.Gene symbolENTPD2
Gene nameectonucleoside triphosphate diphosphohydrolase 2
SynonymsCD39L1|NTPDase-2
CytomapUCSC genome browser: 9q34
Genomic locationchr9 :139942550-139948503
Type of geneprotein-coding
RefGenesNM_001246.3,
NM_203468.2,
Ensembl idENSG00000054179
DescriptionCD39 antigen-like 1NTPDase 2ecto-ATP diphosphohydrolase 2ecto-ATPDase 2ecto-ATPase 2
Modification date20141207
dbXrefs MIM : 602012
HGNC : HGNC
Ensembl : ENSG00000054179
HPRD : 03600
Vega : OTTHUMG00000020953
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENTPD2
BioGPS: 954
Gene Expression Atlas: ENSG00000054179
The Human Protein Atlas: ENSG00000054179
PathwayNCI Pathway Interaction Database: ENTPD2
KEGG: ENTPD2
REACTOME: ENTPD2
ConsensusPathDB
Pathway Commons: ENTPD2
MetabolismMetaCyc: ENTPD2
HUMANCyc: ENTPD2
RegulationEnsembl's Regulation: ENSG00000054179
miRBase: chr9 :139,942,550-139,948,503
TargetScan: NM_001246
cisRED: ENSG00000054179
ContextiHOP: ENTPD2
cancer metabolism search in PubMed: ENTPD2
UCL Cancer Institute: ENTPD2
Assigned class in ccmGDBC

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Phenotypic Information for ENTPD2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ENTPD2
Familial Cancer Database: ENTPD2
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ENTPD2
MedGen: ENTPD2 (Human Medical Genetics with Condition)
ClinVar: ENTPD2
PhenotypeMGI: ENTPD2 (International Mouse Phenotyping Consortium)
PhenomicDB: ENTPD2

Mutations for ENTPD2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryENTPD2chr9139947465139947485chr9139689213139689233
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG958300ENTPD251709139943055139943074CLEC16A65184161127358811273707
AA583398ENTPD211009139942563139942662C1S955231271731197175022

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=11

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=20)
Stat. for Synonymous SNVs
(# total SNVs=15)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:139943429-139943429p.D416D11
chr9:139943112-139943112p.I495I6
chr9:139944736-139944736p.V343V3
chr9:139945765-139945765p.T148T2
chr9:139945809-139945809p.E134*2
chr9:139943209-139943209p.S463F2
chr9:139945549-139945549p.R193R2
chr9:139944352-139944352p.A373A1
chr9:139946009-139946009p.A113A1
chr9:139945389-139945389p.Q247*1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample22 4  1    32   61 1
# mutation32 4  1    32   71 1
nonsynonymous SNV12 2       22   3   
synonymous SNV2  2  1    1    41 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:139945549p.R193R,ENTPD22
chr9:139945765p.T148T,ENTPD22
chr9:139945381p.S450F,ENTPD21
chr9:139946068p.T146T,ENTPD21
chr9:139943179p.A410V,ENTPD21
chr9:139945407p.L128L,ENTPD21
chr9:139946697p.Q383H,ENTPD21
chr9:139943299p.R126C,ENTPD21
chr9:139945421p.A373A,ENTPD21
chr9:139944322p.A123A,ENTPD21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ENTPD2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENTPD2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACTR3B,ANTXRL,ATP1A1,BPI,METTL21C,SAPCD2,CCDC129,
ENTPD2,EPCAM,FGF19,GNAS,KCTD14,LCN2,OR6Q1,
PLSCR5,PTGS2,S100B,SLC13A3,SLC43A3,STX19,TFAP2C
SYNE4,CACFD1,CBLC,ELMO3,ENTPD2,FBXW9,ISYNA1,
LOC92659,LPAR2,LSR,MIA,PAFAH1B3,PKP3,PODNL1,
PPAP2C,PRRG2,RTKN,SPINT1,STXBP2,SYT12,SYTL1

ABCA2,AGPAT2,ALAD,ARRDC1,C9orf142,RABL6,CCDC12,
ENTPD2,EXD3,FBXL8,IGSF8,CCDC183,LOC389332,NDOR1,
NOXA1,NPDC1,PAQR4,PNPLA7,RALGPS1,SH3GLB2,STX19
ACSF3,ADPRHL1,ANKH,LMNTD2,C1orf116,RABL6,CLPTM1,
ENTPD2,EPN1,GIT1,HDAC10,IGSF8,KIAA0195,PGAP2,
POMT1,PRKCSH,RNF128,TMC4,TMEM191A,ZBED1,ZNF784
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENTPD2


There's no related Drug.
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Cross referenced IDs for ENTPD2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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