Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for ENTPD5

Basic gene info.	Gene symbol	ENTPD5
	Gene name	ectonucleoside triphosphate diphosphohydrolase 5
	Synonyms	CD39L4\|NTPDase-5\|PCPH
	Cytomap	UCSC genome browser: 14q24
	Genomic location	chr14 :74433180-74486026
	Type of gene	protein-coding
	RefGenes	NM_001249.2,
	Ensembl id	ENSG00000187097
	Description	CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase ENTPD5
	Modification date	20141207
dbXrefs	MIM : 603162
	HGNC : HGNC
	HPRD : 16015
Protein	UniProt: O75356 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ENTPD5
	BioGPS: 957
	Gene Expression Atlas: ENSG00000187097
	The Human Protein Atlas: ENSG00000187097
Pathway	NCI Pathway Interaction Database: ENTPD5
	KEGG: ENTPD5
	REACTOME: ENTPD5
	ConsensusPathDB
	Pathway Commons: ENTPD5
Metabolism	MetaCyc: ENTPD5
	HUMANCyc: ENTPD5
Regulation	Ensembl's Regulation: ENSG00000187097
	miRBase: chr14 :74,433,180-74,486,026
	TargetScan: NM_001249
	cisRED: ENSG00000187097
Context	iHOP: ENTPD5
	cancer metabolism search in PubMed: ENTPD5
	UCL Cancer Institute: ENTPD5
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ENTPD5 in cancer cell metabolism	1. Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, et al. (2013) Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discov 3: 908-921. doi: 10.1158/2159-8290.CD-12-0507. pmid: 3743121. go to article 2. Zadran S, Amighi A, Otiniano E, Wong K, Zadran H (2012) ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme. Tumour Biol 33: 2411-2421. doi: 10.1007/s13277-012-0505-1. go to article 3. Shen Z, Huang S, Fang M, Wang X (2011) ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells. Cold Spring Harb Symp Quant Biol 76: 217-223. doi: 10.1101/sqb.2011.76.010876. go to article 4. Israelsen WJ, Vander Heiden MG (2010) ATP consumption promotes cancer metabolism. Cell 143: 669-671. doi: 10.1016/j.cell.2010.11.010. go to article 5. MacCarthy CM, Notario V (2013) The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. Int J Oncol 43: 1244-1252. doi: 10.3892/ijo.2013.2052. pmid: 3829800. go to article

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Phenotypic Information for ENTPD5(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: ENTPD5
	Familial Cancer Database: ENTPD5

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM

Others
OMIM	603162; gene.
Orphanet
Disease	KEGG Disease: ENTPD5
	MedGen: ENTPD5 (Human Medical Genetics with Condition)
	ClinVar: ENTPD5
Phenotype	MGI: ENTPD5 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: ENTPD5

Mutations for ENTPD5

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD5 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG402857	ENTPD5	30	81	14	74431132	74431183	ENTPD5	79	724	14	74430496	74431152
AW578884	ENTPD5	31	339	14	74433567	74438597	TCTN3	332	573	10	97423888	97440300

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=21)	Stat. for Synonymous SNVs (# total SNVs=8)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=1)
There's no deleted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr14:74440688-74440688	p.?	2
chr14:74441684-74441684	p.L243L	2
chr14:74444066-74444066	p.I151I	1
chr14:74454758-74454758	p.C16C	1
chr14:74439610-74439610	p.R335Q	1
chr14:74441671-74441671	p.L247W	1
chr14:74444079-74444079	p.?	1
chr14:74439636-74439636	p.F326F	1
chr14:74441683-74441683	p.L243P	1
chr14:74449769-74449769	p.A131A	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		2		3			2		1			1		1			5			2
# mutation		2		3			2		1			1		1			5			2
nonsynonymous SNV		1		1			2							1			1			2
synonymous SNV		1		2					1			1					4

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr14:74440678	p.G201G	1
chr14:74442654	p.G196W	1
chr14:74442670	p.E172K	1
chr14:74436746	p.I151I	1
chr14:74443068	p.A131A	1
chr14:74436806	p.D389D	1
chr14:74443083	p.A131P	1
chr14:74438596	p.F369F	1
chr14:74444005	p.C16C	1
chr14:74439610	p.G348A	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for ENTPD5 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENTPD5

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ARNT2,BMP2K,CCDC176,CARTPT,CHGB,CYBRD1,DIRAS3, ENTPD5,FAM161B,FAM171B,FGF14,GLRA1,GPR26,KCND3, LRP2,OR9A2,SCG2,SORL1,TAT,UCP1,UNC5A	ACADSB,AR,ATP7A,BCAS1,BMP2K,CCDC177,CCDC176, ENTPD5,EXOC2,FAM161B,HCAR1,INPP4B,KIF13B,NLRP8, OR4C15,OR6N1,PFN3,JADE3,RASEF,SNX25,PLEKHD1

ANK3,SOWAHB,CLMN,ENTPD5,EPB41L4B,GPA33,GPD1L, KIAA1161,CIPC,LRRC19,NBEAL1,PDCD4,PLCE1,PLXNA2, SGK2,SLC16A9,SLC35D1,SOS2,SULT1B1,TMEM72,ZNF774	AFG3L2,CDH1,EFTUD1,ENTPD5,EPB41L4B,ERBB3,FZD5, HNF4A,LNX1,LRRC8D,MARVELD2,MFSD9,MYO1D,PLD1, PTPRF,RAB11FIP1,RAPGEFL1,SEMA5A,SNX30,TMEM164,TRAPPC10

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENTPD5

There's no related Drug.

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Cross referenced IDs for ENTPD5

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information