Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ENTPD5
Basic gene info.Gene symbolENTPD5
Gene nameectonucleoside triphosphate diphosphohydrolase 5
SynonymsCD39L4|NTPDase-5|PCPH
CytomapUCSC genome browser: 14q24
Genomic locationchr14 :74433180-74486026
Type of geneprotein-coding
RefGenesNM_001249.2,
Ensembl idENSG00000187097
DescriptionCD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase ENTPD5
Modification date20141207
dbXrefs MIM : 603162
HGNC : HGNC
HPRD : 16015
ProteinUniProt: O75356
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENTPD5
BioGPS: 957
Gene Expression Atlas: ENSG00000187097
The Human Protein Atlas: ENSG00000187097
PathwayNCI Pathway Interaction Database: ENTPD5
KEGG: ENTPD5
REACTOME: ENTPD5
ConsensusPathDB
Pathway Commons: ENTPD5
MetabolismMetaCyc: ENTPD5
HUMANCyc: ENTPD5
RegulationEnsembl's Regulation: ENSG00000187097
miRBase: chr14 :74,433,180-74,486,026
TargetScan: NM_001249
cisRED: ENSG00000187097
ContextiHOP: ENTPD5
cancer metabolism search in PubMed: ENTPD5
UCL Cancer Institute: ENTPD5
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ENTPD5 in cancer cell metabolism1. Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, et al. (2013) Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discov 3: 908-921. doi: 10.1158/2159-8290.CD-12-0507. pmid: 3743121. go to article
2. Zadran S, Amighi A, Otiniano E, Wong K, Zadran H (2012) ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme. Tumour Biol 33: 2411-2421. doi: 10.1007/s13277-012-0505-1. go to article
3. Shen Z, Huang S, Fang M, Wang X (2011) ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells. Cold Spring Harb Symp Quant Biol 76: 217-223. doi: 10.1101/sqb.2011.76.010876. go to article
4. Israelsen WJ, Vander Heiden MG (2010) ATP consumption promotes cancer metabolism. Cell 143: 669-671. doi: 10.1016/j.cell.2010.11.010. go to article
5. MacCarthy CM, Notario V (2013) The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. Int J Oncol 43: 1244-1252. doi: 10.3892/ijo.2013.2052. pmid: 3829800. go to article

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Phenotypic Information for ENTPD5(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ENTPD5
Familial Cancer Database: ENTPD5
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM
KEGG_PYRIMIDINE_METABOLISM

check002.gifOthers
OMIM 603162; gene.
Orphanet
DiseaseKEGG Disease: ENTPD5
MedGen: ENTPD5 (Human Medical Genetics with Condition)
ClinVar: ENTPD5
PhenotypeMGI: ENTPD5 (International Mouse Phenotyping Consortium)
PhenomicDB: ENTPD5

Mutations for ENTPD5
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD5 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BG402857ENTPD53081147443113274431183ENTPD579724147443049674431152
AW578884ENTPD531339147443356774438597TCTN3332573109742388897440300

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample        1 1      
GAIN (# sample)        1 1      
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=21)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr14:74440688-74440688p.?2
chr14:74441684-74441684p.L243L2
chr14:74439685-74439685p.V310G1
chr14:74442654-74442654p.K236R1
chr14:74436730-74436730p.D395H1
chr14:74449813-74449813p.R117*1
chr14:74439698-74439698p.E306*1
chr14:74442670-74442670p.F231L1
chr14:74436746-74436746p.D389D1
chr14:74449816-74449816p.P116S1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 2 3  2 1  1 1  5  2
# mutation 2 3  2 1  1 1  5  2
nonsynonymous SNV 1 1  2      1  1  2
synonymous SNV 1 2    1  1    4   
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr14:74443083p.K236R1
chr14:74438596p.F231L1
chr14:74444005p.G201G1
chr14:74439610p.G196W1
chr14:74444066p.E172K1
chr14:74439636p.I151I1
chr14:74449769p.A131A1
chr14:74439639p.D389D1
chr14:74449771p.A131P1
chr14:74439681p.F369F1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ENTPD5 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENTPD5

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ARNT2,BMP2K,CCDC176,CARTPT,CHGB,CYBRD1,DIRAS3,
ENTPD5,FAM161B,FAM171B,FGF14,GLRA1,GPR26,KCND3,
LRP2,OR9A2,SCG2,SORL1,TAT,UCP1,UNC5A
ACADSB,AR,ATP7A,BCAS1,BMP2K,CCDC177,CCDC176,
ENTPD5,EXOC2,FAM161B,HCAR1,INPP4B,KIF13B,NLRP8,
OR4C15,OR6N1,PFN3,JADE3,RASEF,SNX25,PLEKHD1

ANK3,SOWAHB,CLMN,ENTPD5,EPB41L4B,GPA33,GPD1L,
KIAA1161,CIPC,LRRC19,NBEAL1,PDCD4,PLCE1,PLXNA2,
SGK2,SLC16A9,SLC35D1,SOS2,SULT1B1,TMEM72,ZNF774
AFG3L2,CDH1,EFTUD1,ENTPD5,EPB41L4B,ERBB3,FZD5,
HNF4A,LNX1,LRRC8D,MARVELD2,MFSD9,MYO1D,PLD1,
PTPRF,RAB11FIP1,RAPGEFL1,SEMA5A,SNX30,TMEM164,TRAPPC10
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENTPD5


There's no related Drug.
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Cross referenced IDs for ENTPD5
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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