Cancer Cell Metabolism Gene Database

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory
Cross referenced IDs for 4846
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section
DB CategoryDB NameDB's ID and Url link
Genome annotation databasesEnsembl ENST00000297494; ENSP00000297494; ENSG00000164867.
Genome annotation databasesEnsembl ENST00000484524; ENSP00000420215; ENSG00000164867.
Genome annotation databasesGeneID 4846; -.
Genome annotation databasesKEGG hsa:4846; -.
Genome annotation databasesUCSC uc003wif.3; human. [P29474-1]
Genome annotation databasesUCSC uc011kuz.2; human. [P29474-2]
Sequence databasesCCDS CCDS55182.1; -. [P29474-2]
Sequence databasesCCDS CCDS55183.1; -. [P29474-3]
Sequence databasesCCDS CCDS5912.1; -. [P29474-1]
Sequence databasesEMBL M93718; AAA36364.1; -; mRNA.
Sequence databasesEMBL M95296; AAA36372.1; -; mRNA.
Sequence databasesEMBL L10709; AAA36365.1; -; Genomic_DNA.
Sequence databasesEMBL L10693; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10694; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10695; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10696; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10697; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10698; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10699; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10700; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10701; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10702; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10703; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10704; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10705; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10706; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10707; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10708; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76303; CAA53950.1; -; Genomic_DNA.
Sequence databasesEMBL X76304; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76305; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76306; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76307; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76308; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76309; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76310; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76311; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76312; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76313; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76314; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76315; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76316; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL D26607; BAA05652.1; -; Genomic_DNA.
Sequence databasesEMBL DQ256130; ABB79839.1; -; mRNA.
Sequence databasesEMBL DQ256131; ABB79840.1; -; mRNA.
Sequence databasesEMBL L26914; AAA36374.1; -; Genomic_DNA.
Sequence databasesEMBL AF400594; AAK83389.1; -; mRNA.
Sequence databasesEMBL AK292928; BAF85617.1; -; mRNA.
Sequence databasesEMBL AK315213; BAG37648.1; -; mRNA.
Sequence databasesEMBL AK223636; BAD97356.1; -; mRNA.
Sequence databasesEMBL AF519768; AAM74944.1; -; Genomic_DNA.
Sequence databasesEMBL EU332855; ABY87544.1; -; Genomic_DNA.
Sequence databasesEMBL AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Sequence databasesEMBL CH471173; EAW54069.1; -; Genomic_DNA.
Sequence databasesEMBL BC063294; AAH63294.1; -; mRNA.
Sequence databasesEMBL BC069465; AAH69465.1; -; mRNA.
Sequence databasesEMBL L23210; AAA36373.1; -; Genomic_DNA.
Sequence databasesEMBL S80791; AAD14336.1; -; mRNA.
Sequence databasesPIR A47501; A47501.
Sequence databasesRefSeq NP_000594.2; NM_000603.4.
Sequence databasesRefSeq NP_001153581.1; NM_001160109.1.
Sequence databasesRefSeq NP_001153582.1; NM_001160110.1.
Sequence databasesRefSeq NP_001153583.1; NM_001160111.1.
Sequence databasesRefSeq XP_006716063.1; XM_006716000.1.
Sequence databasesUniGene Hs.647092; -.
Polymorphism databasesDMDM 266648; -.
Gene expression databasesBgee P29474; -.
Gene expression databasesCleanEx HS_NOS3; -.
Gene expression databasesExpressionAtlas P29474; baseline and differential.
Gene expression databasesGenevestigator P29474; -.
OntologiesGO GO:0005901; C:caveola; IDA:BHF-UCL.
OntologiesGO GO:0005737; C:cytoplasm; IDA:BHF-UCL.
OntologiesGO GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
OntologiesGO GO:0005829; C:cytosol; TAS:Reactome.
OntologiesGO GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
OntologiesGO GO:0000139; C:Golgi membrane; TAS:Reactome.
OntologiesGO GO:0005634; C:nucleus; ISS:BHF-UCL.
OntologiesGO GO:0005886; C:plasma membrane; TAS:Reactome.
OntologiesGO GO:0003785; F:actin monomer binding; IPI:BHF-UCL.
OntologiesGO GO:0034618; F:arginine binding; IDA:BHF-UCL.
OntologiesGO GO:0046870; F:cadmium ion binding; NAS:BHF-UCL.
OntologiesGO GO:0050660; F:flavin adenine dinucleotide binding; NAS:BHF-UCL.
OntologiesGO GO:0010181; F:FMN binding; NAS:BHF-UCL.
OntologiesGO GO:0020037; F:heme binding; IDA:BHF-UCL.
OntologiesGO GO:0005506; F:iron ion binding; IEA:InterPro.
OntologiesGO GO:0050661; F:NADP binding; NAS:BHF-UCL.
OntologiesGO GO:0003958; F:NADPH-hemoprotein reductase activity; IBA:RefGenome.
OntologiesGO GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.
OntologiesGO GO:0034617; F:tetrahydrobiopterin binding; IDA:BHF-UCL.
OntologiesGO GO:0001525; P:angiogenesis; IEA:Ensembl.
OntologiesGO GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.
OntologiesGO GO:0007596; P:blood coagulation; TAS:Reactome.
OntologiesGO GO:0001974; P:blood vessel remodeling; ISS:BHF-UCL.
OntologiesGO GO:0043542; P:endothelial cell migration; IMP:BHF-UCL.
OntologiesGO GO:0001701; P:in utero embryonic development; IEA:Ensembl.
OntologiesGO GO:0051701; P:interaction with host; TAS:Reactome.
OntologiesGO GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
OntologiesGO GO:0030324; P:lung development; IEA:Ensembl.
OntologiesGO GO:0007005; P:mitochondrion organization; ISS:BHF-UCL.
OntologiesGO GO:0045776; P:negative regulation of blood pressure; IBA:RefGenome.
OntologiesGO GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
OntologiesGO GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.
OntologiesGO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISS:BHF-UCL.
OntologiesGO GO:0051346; P:negative regulation of hydrolase activity; IEA:Ensembl.
OntologiesGO GO:0014740; P:negative regulation of muscle hyperplasia; ISS:BHF-UCL.
OntologiesGO GO:0010544; P:negative regulation of platelet activation; NAS:BHF-UCL.
OntologiesGO GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
OntologiesGO GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.
OntologiesGO GO:0007263; P:nitric oxide mediated signal transduction; IBA:RefGenome.
OntologiesGO GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.
OntologiesGO GO:0001542; P:ovulation from ovarian follicle; IEA:Ensembl.
OntologiesGO GO:0090382; P:phagosome maturation; TAS:Reactome.
OntologiesGO GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.
OntologiesGO GO:0031284; P:positive regulation of guanylate cyclase activity; IMP:BHF-UCL.
OntologiesGO GO:0045909; P:positive regulation of vasodilation; NAS:BHF-UCL.
OntologiesGO GO:0008217; P:regulation of blood pressure; NAS:BHF-UCL.
OntologiesGO GO:0050880; P:regulation of blood vessel size; ISS:BHF-UCL.
OntologiesGO GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.
OntologiesGO GO:0002028; P:regulation of sodium ion transport; IEA:Ensembl.
OntologiesGO GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IMP:BHF-UCL.
OntologiesGO GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Ensembl.
OntologiesGO GO:0034405; P:response to fluid shear stress; IEP:BHF-UCL.
OntologiesGO GO:0009408; P:response to heat; NAS:BHF-UCL.
OntologiesGO GO:0044281; P:small molecule metabolic process; TAS:Reactome.
OntologiesGO GO:0014806; P:smooth muscle hyperplasia; ISS:BHF-UCL.
Proteomic databasesMaxQB P29474; -.
Proteomic databasesPaxDb P29474; -.
Proteomic databasesPRIDE P29474; -.
Family and domain databasesGene3D 1.20.990.10; -; 1.
Family and domain databasesGene3D 3.40.50.360; -; 2.
Family and domain databasesGene3D 3.90.340.10; -; 1.
Family and domain databasesInterPro IPR003097; FAD-binding_1.
Family and domain databasesInterPro IPR017927; Fd_Rdtase_FAD-bd.
Family and domain databasesInterPro IPR001094; Flavdoxin.
Family and domain databasesInterPro IPR008254; Flavodoxin/NO_synth.
Family and domain databasesInterPro IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
Family and domain databasesInterPro IPR029039; Flavoprotein-like.
Family and domain databasesInterPro IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
Family and domain databasesInterPro IPR012144; NOS_euk.
Family and domain databasesInterPro IPR004030; NOS_N.
Family and domain databasesInterPro IPR001433; OxRdtase_FAD/NAD-bd.
Family and domain databasesInterPro IPR017938; Riboflavin_synthase-like_b-brl.
Family and domain databasesPfam PF00667; FAD_binding_1; 1.
Family and domain databasesPfam PF00258; Flavodoxin_1; 1.
Family and domain databasesPfam PF00175; NAD_binding_1; 1.
Family and domain databasesPfam PF02898; NO_synthase; 1.
Family and domain databasesPIRSF PIRSF000333; NOS; 1.
Family and domain databasesPRINTS PR00369; FLAVODOXIN.
Family and domain databasesPRINTS PR00371; FPNCR.
Family and domain databasesPROSITE PS51384; FAD_FR; 1.
Family and domain databasesPROSITE PS50902; FLAVODOXIN_LIKE; 1.
Family and domain databasesPROSITE PS60001; NOS; 1.
Family and domain databasesSUPFAM SSF52218; SSF52218; 1.
Family and domain databasesSUPFAM SSF56512; SSF56512; 1.
Family and domain databasesSUPFAM SSF63380; SSF63380; 1.
PTM databasesPhosphoSite P29474; -.
Protein-protein interaction databasesBioGrid 110909; 44.
Protein-protein interaction databasesDIP DIP-38479N; -.
Protein-protein interaction databasesIntAct P29474; 29.
Protein-protein interaction databasesMINT MINT-106980; -.
Enzyme and pathway databasesBioCyc MetaCyc:HS09149-MONOMER; -.
Enzyme and pathway databasesReactome REACT_111176; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
Enzyme and pathway databasesReactome REACT_121256; Phagosomal maturation (early endosomal stage).
Enzyme and pathway databasesReactome REACT_12477; eNOS activation.
Enzyme and pathway databasesReactome REACT_12510; NOSIP mediated eNOS trafficking.
Enzyme and pathway databasesReactome REACT_12541; NOSTRIN mediated eNOS trafficking.
Enzyme and pathway databasesReactome REACT_228016; VEGFR2 mediated vascular permeability.
Enzyme and pathway databasesReactome REACT_23862; Nitric oxide stimulates guanylate cyclase.
Enzyme and pathway databasesSignaLink P29474; -.
3D structure databasesPDB 1M9J; X-ray; 2.43 A; A/B=67-481.
3D structure databasesPDB 1M9K; X-ray; 2.01 A; A/B=67-481.
3D structure databasesPDB 1M9M; X-ray; 1.96 A; A/B=67-481.
3D structure databasesPDB 1M9Q; X-ray; 2.01 A; A/B=67-481.
3D structure databasesPDB 1M9R; X-ray; 2.56 A; A/B=67-481.
3D structure databasesPDB 1NIW; X-ray; 2.05 A; B/D/F/H=492-511.
3D structure databasesPDB 2LL7; NMR; -; B=493-509.
3D structure databasesPDB 2MG5; NMR; -; B=495-510.
3D structure databasesPDB 3EAH; X-ray; 2.44 A; A/B=66-492.
3D structure databasesPDB 3NOS; X-ray; 2.40 A; A/B=66-492.
3D structure databasesPDBsum 1M9J; -.
3D structure databasesPDBsum 1M9K; -.
3D structure databasesPDBsum 1M9M; -.
3D structure databasesPDBsum 1M9Q; -.
3D structure databasesPDBsum 1M9R; -.
3D structure databasesPDBsum 1NIW; -.
3D structure databasesPDBsum 2LL7; -.
3D structure databasesPDBsum 2MG5; -.
3D structure databasesPDBsum 3EAH; -.
3D structure databasesPDBsum 3NOS; -.
3D structure databasesProteinModelPortal P29474; -.
3D structure databasesSMR P29474; 67-481, 492-1177.
Protocols and materials databasesDNASU 4846; -.
Phylogenomic databaseseggNOG COG4362; -.
Phylogenomic databasesGeneTree ENSGT00620000087711; -.
Phylogenomic databasesHOGENOM HOG000111088; -.
Phylogenomic databasesHOVERGEN HBG000159; -.
Phylogenomic databasesInParanoid P29474; -.
Phylogenomic databasesKO K13242; -.
Phylogenomic databasesOrthoDB EOG79SDW7; -.
Phylogenomic databasesPhylomeDB P29474; -.
Phylogenomic databasesTreeFam TF324410; -.
Organism-specific databasesCTD 4846; -.
Organism-specific databasesGeneCards GC07P150688; -.
Organism-specific databasesH-InvDB HIX0033558; -.
Organism-specific databasesHGNC HGNC:7876; NOS3.
Organism-specific databasesHPA CAB002168; -.
Organism-specific databasesMIM 163729; gene+phenotype.
Organism-specific databasesneXtProt NX_P29474; -.
Organism-specific databasesPharmGKB PA254; -.
ChemistryBindingDB P29474; -.
ChemistryChEMBL CHEMBL2111405; -.
ChemistryDrugBank DB00997; Doxorubicin.
ChemistryDrugBank DB00125; L-Arginine.
ChemistryDrugBank DB00155; L-Citrulline.
ChemistryDrugBank DB01110; Miconazole.
ChemistryDrugBank DB00360; Tetrahydrobiopterin.
OtherChiTaRS NOS3; human.
OtherEvolutionaryTrace P29474; -.
OtherGeneWiki Endothelial_NOS; -.
OtherGenomeRNAi 4846; -.
OtherNextBio 18666; -.
OtherPRO PR:P29474; -.
Genome annotation databasesEnsembl ENST00000297494; ENSP00000297494; ENSG00000164867.
Genome annotation databasesEnsembl ENST00000484524; ENSP00000420215; ENSG00000164867.
Genome annotation databasesGeneID 4846; -.
Genome annotation databasesKEGG hsa:4846; -.
Genome annotation databasesUCSC uc003wif.3; human. [P29474-1]
Genome annotation databasesUCSC uc011kuz.2; human. [P29474-2]
Sequence databasesCCDS CCDS55182.1; -. [P29474-2]
Sequence databasesCCDS CCDS55183.1; -. [P29474-3]
Sequence databasesCCDS CCDS5912.1; -. [P29474-1]
Sequence databasesEMBL M93718; AAA36364.1; -; mRNA.
Sequence databasesEMBL M95296; AAA36372.1; -; mRNA.
Sequence databasesEMBL L10709; AAA36365.1; -; Genomic_DNA.
Sequence databasesEMBL L10693; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10694; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10695; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10696; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10697; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10698; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10699; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10700; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10701; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10702; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10703; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10704; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10705; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10706; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10707; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL L10708; AAA36365.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76303; CAA53950.1; -; Genomic_DNA.
Sequence databasesEMBL X76304; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76305; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76306; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76307; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76308; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76309; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76310; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76311; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76312; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76313; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76314; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76315; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL X76316; CAA53950.1; JOINED; Genomic_DNA.
Sequence databasesEMBL D26607; BAA05652.1; -; Genomic_DNA.
Sequence databasesEMBL DQ256130; ABB79839.1; -; mRNA.
Sequence databasesEMBL DQ256131; ABB79840.1; -; mRNA.
Sequence databasesEMBL L26914; AAA36374.1; -; Genomic_DNA.
Sequence databasesEMBL AF400594; AAK83389.1; -; mRNA.
Sequence databasesEMBL AK292928; BAF85617.1; -; mRNA.
Sequence databasesEMBL AK315213; BAG37648.1; -; mRNA.
Sequence databasesEMBL AK223636; BAD97356.1; -; mRNA.
Sequence databasesEMBL AF519768; AAM74944.1; -; Genomic_DNA.
Sequence databasesEMBL EU332855; ABY87544.1; -; Genomic_DNA.
Sequence databasesEMBL AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Sequence databasesEMBL CH471173; EAW54069.1; -; Genomic_DNA.
Sequence databasesEMBL BC063294; AAH63294.1; -; mRNA.
Sequence databasesEMBL BC069465; AAH69465.1; -; mRNA.
Sequence databasesEMBL L23210; AAA36373.1; -; Genomic_DNA.
Sequence databasesEMBL S80791; AAD14336.1; -; mRNA.
Sequence databasesPIR A47501; A47501.
Sequence databasesRefSeq NP_000594.2; NM_000603.4.
Sequence databasesRefSeq NP_001153581.1; NM_001160109.1.
Sequence databasesRefSeq NP_001153582.1; NM_001160110.1.
Sequence databasesRefSeq NP_001153583.1; NM_001160111.1.
Sequence databasesRefSeq XP_006716063.1; XM_006716000.1.
Sequence databasesUniGene Hs.647092; -.
Polymorphism databasesDMDM 266648; -.
Gene expression databasesBgee P29474; -.
Gene expression databasesCleanEx HS_NOS3; -.
Gene expression databasesExpressionAtlas P29474; baseline and differential.
Gene expression databasesGenevestigator P29474; -.
OntologiesGO GO:0005901; C:caveola; IDA:BHF-UCL.
OntologiesGO GO:0005737; C:cytoplasm; IDA:BHF-UCL.
OntologiesGO GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
OntologiesGO GO:0005829; C:cytosol; TAS:Reactome.
OntologiesGO GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
OntologiesGO GO:0000139; C:Golgi membrane; TAS:Reactome.
OntologiesGO GO:0005634; C:nucleus; ISS:BHF-UCL.
OntologiesGO GO:0005886; C:plasma membrane; TAS:Reactome.
OntologiesGO GO:0003785; F:actin monomer binding; IPI:BHF-UCL.
OntologiesGO GO:0034618; F:arginine binding; IDA:BHF-UCL.
OntologiesGO GO:0046870; F:cadmium ion binding; NAS:BHF-UCL.
OntologiesGO GO:0050660; F:flavin adenine dinucleotide binding; NAS:BHF-UCL.
OntologiesGO GO:0010181; F:FMN binding; NAS:BHF-UCL.
OntologiesGO GO:0020037; F:heme binding; IDA:BHF-UCL.
OntologiesGO GO:0005506; F:iron ion binding; IEA:InterPro.
OntologiesGO GO:0050661; F:NADP binding; NAS:BHF-UCL.
OntologiesGO GO:0003958; F:NADPH-hemoprotein reductase activity; IBA:RefGenome.
OntologiesGO GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.
OntologiesGO GO:0034617; F:tetrahydrobiopterin binding; IDA:BHF-UCL.
OntologiesGO GO:0001525; P:angiogenesis; IEA:Ensembl.
OntologiesGO GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.
OntologiesGO GO:0007596; P:blood coagulation; TAS:Reactome.
OntologiesGO GO:0001974; P:blood vessel remodeling; ISS:BHF-UCL.
OntologiesGO GO:0043542; P:endothelial cell migration; IMP:BHF-UCL.
OntologiesGO GO:0001701; P:in utero embryonic development; IEA:Ensembl.
OntologiesGO GO:0051701; P:interaction with host; TAS:Reactome.
OntologiesGO GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
OntologiesGO GO:0030324; P:lung development; IEA:Ensembl.
OntologiesGO GO:0007005; P:mitochondrion organization; ISS:BHF-UCL.
OntologiesGO GO:0045776; P:negative regulation of blood pressure; IBA:RefGenome.
OntologiesGO GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
OntologiesGO GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.
OntologiesGO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISS:BHF-UCL.
OntologiesGO GO:0051346; P:negative regulation of hydrolase activity; IEA:Ensembl.
OntologiesGO GO:0014740; P:negative regulation of muscle hyperplasia; ISS:BHF-UCL.
OntologiesGO GO:0010544; P:negative regulation of platelet activation; NAS:BHF-UCL.
OntologiesGO GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
OntologiesGO GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.
OntologiesGO GO:0007263; P:nitric oxide mediated signal transduction; IBA:RefGenome.
OntologiesGO GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.
OntologiesGO GO:0001542; P:ovulation from ovarian follicle; IEA:Ensembl.
OntologiesGO GO:0090382; P:phagosome maturation; TAS:Reactome.
OntologiesGO GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.
OntologiesGO GO:0031284; P:positive regulation of guanylate cyclase activity; IMP:BHF-UCL.
OntologiesGO GO:0045909; P:positive regulation of vasodilation; NAS:BHF-UCL.
OntologiesGO GO:0008217; P:regulation of blood pressure; NAS:BHF-UCL.
OntologiesGO GO:0050880; P:regulation of blood vessel size; ISS:BHF-UCL.
OntologiesGO GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.
OntologiesGO GO:0002028; P:regulation of sodium ion transport; IEA:Ensembl.
OntologiesGO GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IMP:BHF-UCL.
OntologiesGO GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Ensembl.
OntologiesGO GO:0034405; P:response to fluid shear stress; IEP:BHF-UCL.
OntologiesGO GO:0009408; P:response to heat; NAS:BHF-UCL.
OntologiesGO GO:0044281; P:small molecule metabolic process; TAS:Reactome.
OntologiesGO GO:0014806; P:smooth muscle hyperplasia; ISS:BHF-UCL.
Proteomic databasesMaxQB P29474; -.
Proteomic databasesPaxDb P29474; -.
Proteomic databasesPRIDE P29474; -.
Family and domain databasesGene3D 1.20.990.10; -; 1.
Family and domain databasesGene3D 3.40.50.360; -; 2.
Family and domain databasesGene3D 3.90.340.10; -; 1.
Family and domain databasesInterPro IPR003097; FAD-binding_1.
Family and domain databasesInterPro IPR017927; Fd_Rdtase_FAD-bd.
Family and domain databasesInterPro IPR001094; Flavdoxin.
Family and domain databasesInterPro IPR008254; Flavodoxin/NO_synth.
Family and domain databasesInterPro IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
Family and domain databasesInterPro IPR029039; Flavoprotein-like.
Family and domain databasesInterPro IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
Family and domain databasesInterPro IPR012144; NOS_euk.
Family and domain databasesInterPro IPR004030; NOS_N.
Family and domain databasesInterPro IPR001433; OxRdtase_FAD/NAD-bd.
Family and domain databasesInterPro IPR017938; Riboflavin_synthase-like_b-brl.
Family and domain databasesPfam PF00667; FAD_binding_1; 1.
Family and domain databasesPfam PF00258; Flavodoxin_1; 1.
Family and domain databasesPfam PF00175; NAD_binding_1; 1.
Family and domain databasesPfam PF02898; NO_synthase; 1.
Family and domain databasesPIRSF PIRSF000333; NOS; 1.
Family and domain databasesPRINTS PR00369; FLAVODOXIN.
Family and domain databasesPRINTS PR00371; FPNCR.
Family and domain databasesPROSITE PS51384; FAD_FR; 1.
Family and domain databasesPROSITE PS50902; FLAVODOXIN_LIKE; 1.
Family and domain databasesPROSITE PS60001; NOS; 1.
Family and domain databasesSUPFAM SSF52218; SSF52218; 1.
Family and domain databasesSUPFAM SSF56512; SSF56512; 1.
Family and domain databasesSUPFAM SSF63380; SSF63380; 1.
PTM databasesPhosphoSite P29474; -.
Protein-protein interaction databasesBioGrid 110909; 44.
Protein-protein interaction databasesDIP DIP-38479N; -.
Protein-protein interaction databasesIntAct P29474; 29.
Protein-protein interaction databasesMINT MINT-106980; -.
Enzyme and pathway databasesBioCyc MetaCyc:HS09149-MONOMER; -.
Enzyme and pathway databasesReactome REACT_111176; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
Enzyme and pathway databasesReactome REACT_121256; Phagosomal maturation (early endosomal stage).
Enzyme and pathway databasesReactome REACT_12477; eNOS activation.
Enzyme and pathway databasesReactome REACT_12510; NOSIP mediated eNOS trafficking.
Enzyme and pathway databasesReactome REACT_12541; NOSTRIN mediated eNOS trafficking.
Enzyme and pathway databasesReactome REACT_228016; VEGFR2 mediated vascular permeability.
Enzyme and pathway databasesReactome REACT_23862; Nitric oxide stimulates guanylate cyclase.
Enzyme and pathway databasesSignaLink P29474; -.
3D structure databasesPDB 1M9J; X-ray; 2.43 A; A/B=67-481.
3D structure databasesPDB 1M9K; X-ray; 2.01 A; A/B=67-481.
3D structure databasesPDB 1M9M; X-ray; 1.96 A; A/B=67-481.
3D structure databasesPDB 1M9Q; X-ray; 2.01 A; A/B=67-481.
3D structure databasesPDB 1M9R; X-ray; 2.56 A; A/B=67-481.
3D structure databasesPDB 1NIW; X-ray; 2.05 A; B/D/F/H=492-511.
3D structure databasesPDB 2LL7; NMR; -; B=493-509.
3D structure databasesPDB 2MG5; NMR; -; B=495-510.
3D structure databasesPDB 3EAH; X-ray; 2.44 A; A/B=66-492.
3D structure databasesPDB 3NOS; X-ray; 2.40 A; A/B=66-492.
3D structure databasesPDBsum 1M9J; -.
3D structure databasesPDBsum 1M9K; -.
3D structure databasesPDBsum 1M9M; -.
3D structure databasesPDBsum 1M9Q; -.
3D structure databasesPDBsum 1M9R; -.
3D structure databasesPDBsum 1NIW; -.
3D structure databasesPDBsum 2LL7; -.
3D structure databasesPDBsum 2MG5; -.
3D structure databasesPDBsum 3EAH; -.
3D structure databasesPDBsum 3NOS; -.
3D structure databasesProteinModelPortal P29474; -.
3D structure databasesSMR P29474; 67-481, 492-1177.
Protocols and materials databasesDNASU 4846; -.
Phylogenomic databaseseggNOG COG4362; -.
Phylogenomic databasesGeneTree ENSGT00620000087711; -.
Phylogenomic databasesHOGENOM HOG000111088; -.
Phylogenomic databasesHOVERGEN HBG000159; -.
Phylogenomic databasesInParanoid P29474; -.
Phylogenomic databasesKO K13242; -.
Phylogenomic databasesOrthoDB EOG79SDW7; -.
Phylogenomic databasesPhylomeDB P29474; -.
Phylogenomic databasesTreeFam TF324410; -.
Organism-specific databasesCTD 4846; -.
Organism-specific databasesGeneCards GC07P150688; -.
Organism-specific databasesH-InvDB HIX0033558; -.
Organism-specific databasesHGNC HGNC:7876; NOS3.
Organism-specific databasesHPA CAB002168; -.
Organism-specific databasesMIM 163729; gene+phenotype.
Organism-specific databasesneXtProt NX_P29474; -.
Organism-specific databasesPharmGKB PA254; -.
ChemistryBindingDB P29474; -.
ChemistryChEMBL CHEMBL2111405; -.
ChemistryDrugBank DB00997; Doxorubicin.
ChemistryDrugBank DB00125; L-Arginine.
ChemistryDrugBank DB00155; L-Citrulline.
ChemistryDrugBank DB01110; Miconazole.
ChemistryDrugBank DB00360; Tetrahydrobiopterin.
OtherChiTaRS NOS3; human.
OtherEvolutionaryTrace P29474; -.
OtherGeneWiki Endothelial_NOS; -.
OtherGenomeRNAi 4846; -.
OtherNextBio 18666; -.
OtherPRO PR:P29474; -.



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