DegronMD - A1A4G5(LNP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E96K	TCGA-55-7281	LUAD	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.E96K	DO25985	LUAD	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.R79G	TCGA-97-8176	LUAD	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.R79G	DO218933	LUAD	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.R79C	TCGA-A7-A13D	BRCA	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.R79C	DO1392	BRCA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1944
p.E96G	TCGA-AH-6644	READ	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.E96G	DO37237	READ	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.R86I	TCGA-AX-A0J0	UCEC	TCGA	DYR	CBL_MET	84:86	Mutation altering degron motif	0.8102
p.R86I	DO41133	UCEC	ICGC	DYR	CBL_MET	84:86	Mutation altering degron motif	0.8102
p.V82A	TCGA-BR-8680	STAD	TCGA	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2778
p.V82A	DO47769	STAD	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.2778
p.D84N	TCGA-CD-8535	STAD	TCGA	DYR	CBL_MET	84:86	Mutation altering degron motif	0.6932
p.D84N	DO47741	STAD	ICGC	DYR	CBL_MET	84:86	Mutation altering degron motif	0.6932
p.D84Y	DO229019	LICA	ICGC	DYR	CBL_MET	84:86	Mutation altering degron motif	0.7325
p.E96D	DO229026	LICA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0556
p.C78F	DO229036	LICA	ICGC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.1667
p.E75K	SIDM01159	Other Sarcomas	GDSC	DYR	CBL_MET	84:86	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons