DegronMD - A6NCL1(GMNC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H254Y	TCGA-D1-A101	UCEC	TCGA	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1111
p.H254Y	DO43955	UCEC	ICGC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1111
p.D244Y	DO222798	COCA	ICGC	DYR	CBL_MET	244:246	Mutation altering degron motif	0.7325
p.M241T	DO230522	LUSC	ICGC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.25
p.S255N	DO232224	PBCA	ICGC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.0833
p.T250R	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00798	Rhabdomyosarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00234	Other Solid Cancers	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01090	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01237	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00088	Prostate Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00198	Ewing's Sarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01199	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00961	Ewing's Sarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01177	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00789	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00305	Ovarian Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00311	Mesothelioma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00974	Melanoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00779	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01180	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00183	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00081	Melanoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01082	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00612	Glioma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00828	Other Sarcomas	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00836	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00373	Endometrial Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01217	Other Blood Cancers	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00241	Breast Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM00132	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01083	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01018	Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01648	Non-Cancerous	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.T250R	SIDM01138	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.2222
p.E239Q	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00798	Rhabdomyosarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00234	Other Solid Cancers	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01090	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01237	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00088	Prostate Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00198	Ewing's Sarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01199	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00961	Ewing's Sarcoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01177	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00789	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00305	Ovarian Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00311	Mesothelioma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00974	Melanoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00779	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01180	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00183	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00081	Melanoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01082	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00612	Glioma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00828	Other Sarcomas	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00836	Colorectal Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00373	Endometrial Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01217	Other Blood Cancers	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00241	Breast Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM00132	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01083	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01018	Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01648	Non-Cancerous	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.E239Q	SIDM01138	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1944
p.L253M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1389
p.L253M	ACH-000766	Lung Cancer	CCLE	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1389
p.L253M	NCI-H1648	lung	COSMIC	DYR	CBL_MET	244:246	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMNC

UniProt ID: A6NCL1

Entrez ID: 647309

Protein name: Geminin coiled-coil domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMNC in