DegronMD - A6NEL2(SOWAHB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E751Q	TCGA-91-6848	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0833
p.E751Q	DO23846	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0833
p.S749R	TCGA-BR-4256	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1389
p.S749R	DO38743	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1389
p.S741Y	TCGA-EI-6917	READ	TCGA	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.712
p.S741Y	DO36881	READ	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.712
p.R745T	TCGA-XF-AAN0	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.R745T	DO51941	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.S742Y	DO229015	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.712
p.T744N	DO229022	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.Y735H	SIDM00989	Bladder Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.Y735H	ACH-000802	Bladder Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.Y735H	BFTC-905	urinary tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.L737S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056
p.L737S	ACH-000951	Lung Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056
p.L737S	NCI-H2342	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056

Kaplan plot for SOWAHB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOWAHB

UniProt ID: A6NEL2

Entrez ID: 345079

Protein name: Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOWAHB in