EPOP
UniProt ID: A6NHQ4
Entrez ID: 100170841
Protein name: Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active an...
FUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}.
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GO - Biological processes (BP):
histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]...
histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]...
chromatin binding [GO:0003682]
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GO - Cellular component (CC):
chromosome [GO:0005694]; elongin complex [GO:0070449]; ESC/E(Z) complex [GO:0035098]...
chromosome [GO:0005694]; elongin complex [GO:0070449]; ESC/E(Z) complex [GO:0035098]
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EPOP
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*NOTE: the Kaplan plots were collected from OncoLnc