DegronMD - A6NNA5(DRGX)

DRGX

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P239S	TCGA-22-4613	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation substituting flanking lysine	0.25
p.A229T	TCGA-AJ-A3OJ	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7139
p.R219C	TCGA-OR-A5J5	ACC	TCGA	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0833
p.S223L	DO225116	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1944
p.S223L	DO227517	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1944
p.S231I	DO222460	BTCA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7341
p.A238T	DO7810	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1667
p.A241V	DO223076	ESCA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0833
p.A241E	DO229028	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0833
p.P234S	DO26468	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.2778
p.P242T	DO50676	ORCA	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0556
p.P240L	DO41871	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1111
p.P240L	DO41361	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1111
p.P240L	SIDM01746	Osteosarcoma	GDSC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.1111
p.A224T	DO42753	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc