USP27X
UniProt ID: A6NNY8
Entrez ID: 389856
Protein name: Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and DDX58/RIG-I (PubMed:31534008, PubMed:32027733). Negatively regulates DDX58/RIG-I by mediating 'Lys-63'-linked deubiquitination of DDX58/RIG-I, inhibiting type I interferon signaling (PubMed:32027...
FUNCTION: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and DDX58/RIG-I (PubMed:31534008, PubMed:32027733). Negatively regulates DDX58/RIG-I by mediating 'Lys-63'-linked deubiquitination of DDX58/RIG-I, inhibiting type I interferon signaling (PubMed:32027733). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (PubMed:32027733). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity). {ECO:0000250|UniProtKB:Q8CEG8, ECO:0000269|PubMed:31534008, ECO:0000269|PubMed:32027733}.
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GO - Biological processes (BP):
defense response to virus [GO:0051607]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitinatio...
defense response to virus [GO:0051607]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511]
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GO - Molecular function (MF):
cysteine-type endopeptidase activity [GO:0004197]; Lys48-specific deubiquitinase activity [GO:1990380]; Lys63-specific deubiquitinase activity [GO:0061578]; thiol-dependent deubiquitinase [GO:0004843]...
cysteine-type endopeptidase activity [GO:0004197]; Lys48-specific deubiquitinase activity [GO:1990380]; Lys63-specific deubiquitinase activity [GO:0061578]; thiol-dependent deubiquitinase [GO:0004843]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleus [GO:0005634]...
cytosol [GO:0005829]; nucleus [GO:0005634]
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USP27X
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*NOTE: the Kaplan plots were collected from OncoLnc