DegronMD - A7MBM2(DISP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P74T	TCGA-85-6798	LUSC	TCGA	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation altering degron motif	0.5919
p.P74T	DO27295	LUSC	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation altering degron motif	0.5919
p.P72S	TCGA-B5-A3FC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72S	TCGA-B5-A3FC	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.P72S	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72S	DO41871	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.P72L	TCGA-CV-6940	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72L	TCGA-CV-6940	HNSC	TCGA	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.P72L	DO15903	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72L	DO15903	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.S69F	TCGA-DK-A3WW	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7982
p.S69F	DO481	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7982
p.L58F	TCGA-EE-A182	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.L58F	DO37814	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.P84S	TCGA-EE-A3AA	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.P84S	DO222632	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.P84S	DO37571	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.P87L	TCGA-FW-A3R5	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.0556
p.P87L	DO37406	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.0556
p.C56S	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.C56S	DO229013	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.C56S	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.C56S	DO229003	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.C56S	DO229005	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.G71V	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.G71V	DO228978	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.2778
p.D65Y	DO229015	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.D65Y	DO229015	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1111
p.V82L	DO229031	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1944
p.H59Y	DO222402	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.P84L	DO222536	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.S69Y	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.712
p.S69Y	ACH-000408	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.712
p.S69Y	TE-5	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.712
p.S68I	SIDM01128	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7341
p.S68I	ACH-000767	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7341
p.S68I	NCI-H526	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7341
p.Q80R	SIDM01575	Plasma Cell Myeloma	GDSC	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.Q80R	SIDM01575	Plasma Cell Myeloma	GDSC	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.25
p.Q80R	ACH-000426	Myeloma	CCLE	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.Q80R	ACH-000426	Myeloma	CCLE	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.25
p.D65G	ACH-001610	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.D65G	ACH-001610	Brain Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DISP2

UniProt ID: A7MBM2

Entrez ID: 85455

Protein name: Protein dispatched homolog 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DISP2 in