DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
ERVV-1
UniProt ID:
B6SEH8
Entrez ID:
147664
Protein name:
Endogenous retrovirus group V member 1 Env polyprotein (HERV-V_19q13.41 provirus ancestral Env polyprotein 1)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]...
integral component of membrane [GO:0016021]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
ERVV-1
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Show Degron:
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.C258R
DO225280
BRCA
ICGC
PPGY
ITCH
251:254
Mutation rewiring degron network
0.2222
p.D241N
DO222769
COCA
ICGC
PPGY
ITCH
251:254
Mutation rewiring degron network
0.0556
p.G253D
DO222798
COCA
ICGC
PPGY
ITCH
251:254
Mutation altering degron motif
0.6087
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for ERVV-1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc