DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C5orf67
UniProt ID:
F2Z3F1
Entrez ID:
Protein name:
Uncharacterized protein C5orf67
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
C5orf67
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.L51I
SIDM00973
Melanoma
GDSC
DYR
CBL_MET
42:44
Mutation rewiring degron network
0.1389
p.G49D
SIDM00596
Endometrial Carcinoma
GDSC
DYR
CBL_MET
42:44
Mutation rewiring degron network
0.1944
p.T45A
SIDM01088
Endometrial Carcinoma
GDSC
DYR
CBL_MET
42:44
Mutation rewiring degron network
0.3056
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C5orf67 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc