DegronMD - F5H4B4(FAM227A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K336T	TCGA-D1-A16X	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.K336T	DO41799	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.K336T	HCC2998	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.Q341R	TCGA-DF-A2KN	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.S347L	TCGA-EK-A3GK	CESC	TCGA	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.8778
p.S347L	DO49964	CESC	ICGC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.8778
p.N358K	DO229019	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.H339N	DO229034	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1667
p.K336E	DO229216	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.S358F	SIDM00679	Cervical Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.S358F	HT-3	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.S348C	SIDM00679	Cervical Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.8652
p.S348C	HT-3	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.8652
p.K341T	SIDM00118	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.K341T	ACH-001081	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.K341T	HCC2998	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.S343C	HT-3	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation blocking phosphorylation signal	0.7222
p.S359L	HT-3	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0556
p.S353F	HT-3	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM227A

UniProt ID: F5H4B4

Entrez ID: 646851

Protein name: Protein FAM227A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM227A in