DegronMD - O00160(MYO1F)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P985L	TCGA-A5-A2K3	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.6471
p.P985L	TCGA-CN-5356	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.6471
p.P985L	DO15390	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.6471
p.P985L	DO43899	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.6471
p.P984H	TCGA-BF-A1Q0	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.7694
p.P984H	DO47374	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.7694
p.R994Q	TCGA-D3-A1Q7	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1667
p.R994Q	DO222595	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1667
p.R994Q	DO37981	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1667
p.G990A	TCGA-E9-A1R4	BRCA	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.G990A	DO5815	BRCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R982L	TCGA-EE-A2MG	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R982L	DO37421	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.S986F	TCGA-TQ-A7RQ	LGG	TCGA	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.7982
p.S986F	DO223693	LGG	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.7982
p.R982W	DO227549	COCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R982W	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R982W	ACH-000789	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R982W	NCI-H810	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.2778
p.R994P	DO44726	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1667
p.A997E	DO50681	ORCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.0833
p.S988F	DO232761	PBCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.9093
p.P981L	DO229467	SKCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.25
p.R998H	DO229208	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.0556
p.R998H	SIDM00789	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.0556
p.P985S	SIDM00392	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P985S	SIDM01175	Other Sarcomas	GDSC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P985S	ACH-000810	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P985S	ACH-002309	Sarcoma	CCLE	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P985S	SW684	soft tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P985S	SK-MEL-30	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation altering degron motif	0.5641
p.P995S	ACH-000779	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	984:988	Mutation rewiring degron network	0.1389

Kaplan plot for MYO1F in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO1F

UniProt ID: O00160

Entrez ID: 4542

Protein name: Unconventional myosin-If (Myosin-Ie)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO1F in