DegronMD - O00257(CBX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A504V	TCGA-HU-A4GX	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1667
p.A504V	DO47757	STAD	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1667
p.P519A	TCGA-IA-A40Y	KIRP	TCGA	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.P519A	DO44462	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.V505A	TCGA-OR-A5JM	ACC	TCGA	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.V505A	DO222877	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.V505A	DO49680	LIAD	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.V505A	DO44740	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.V505A	DO231257	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.P519S	DO11854	GBM	ICGC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1944
p.A508V	SIDM01307	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.2778
p.V503A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1389
p.V503A	ACH-002256	Leukemia	CCLE	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1389
p.P511L	SIDM01608	Endometrial Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	510:514	Mutation altering degron motif	0.6471
p.P511L	ACH-000990	Endometrial/Uterine Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	510:514	Mutation altering degron motif	0.6471
p.D524N	ACH-001814	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556

Kaplan plot for CBX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBX4

UniProt ID: O00257

Entrez ID: 8535

Protein name: E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBX4 in