DegronMD - O00712(NFIB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G216R	TCGA-AP-A1DK	UCEC	TCGA	PPGY	ITCH	204:207	Mutation rewiring degron network	0.0833
p.G216R	DO42033	UCEC	ICGC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.0833
p.S211N	TCGA-AX-A1CE	UCEC	TCGA	PPGY	ITCH	204:207	Mutation blocking phosphorylation signal	0.6667
p.S211N	DO42280	UCEC	ICGC	PPGY	ITCH	204:207	Mutation blocking phosphorylation signal	0.6667
p.A201T	TCGA-AZ-4315	COAD	TCGA	PPGY	ITCH	204:207	Mutation rewiring degron network	0.25
p.A201T	DO8842	COAD	ICGC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.25
p.S194R	TCGA-E2-A14V	BRCA	TCGA	PPGY	ITCH	204:207	Mutation blocking phosphorylation signal	0.5
p.S194R	DO3548	BRCA	ICGC	PPGY	ITCH	204:207	Mutation blocking phosphorylation signal	0.5
p.E209D	TCGA-EE-A17Z	SKCM	TCGA	PPGY	ITCH	204:207	Mutation rewiring degron network	0.2778
p.E209D	DO37921	SKCM	ICGC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.2778
p.N198S	SIDM00845	Burkitt's Lymphoma	GDSC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.N198S	SIDM01519	Head and Neck Carcinoma	GDSC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.N198S	ACH-000786	Lymphoma	CCLE	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.N198S	ACH-000992	Head and Neck Cancer	CCLE	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1667
p.L208F	SIDM00333	Endometrial Carcinoma	GDSC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.L208F	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.L208F	MFE-319	endometrium	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.L208P	ACH-001853	Bile Duct Cancer	CCLE	PPGY	ITCH	204:207	Mutation rewiring degron network	0.3056
p.Q217R	MFE-319	endometrium	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.0556
p.D199G	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.P206L	SW684	soft tissue	COSMIC	PPGY	ITCH	204:207	Mutation altering degron motif	0.7582
p.S197T	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1389
p.S197T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1389
p.S197T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1389
p.T199R	SW1271	lung	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.1944
p.S200L	LoVo	large intestine	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.2222
p.L204F	MFE-319	endometrium	COSMIC	PPGY	ITCH	204:207	Mutation altering degron motif	0.6981
p.D195G	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	204:207	Mutation rewiring degron network	0.0833

Kaplan plot for NFIB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFIB

UniProt ID: O00712

Entrez ID: 4781

Protein name: Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFIB in