DegronMD - O14668(PRRG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S184T	TCGA-66-2780	LUSC	TCGA	PPEY	ITCH	193:196	Mutation blocking phosphorylation signal	0.5278
p.S184T	DO26953	LUSC	ICGC	PPEY	ITCH	193:196	Mutation blocking phosphorylation signal	0.5278
p.R162C	TCGA-A5-A1OF	UCEC	TCGA	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162C	DO222880	MELA	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162C	DO42568	UCEC	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	TCGA-AF-6672	READ	TCGA	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	DO36937	READ	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	ACH-000200	Brain Cancer	CCLE	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	ACH-000452	Esophageal Cancer	CCLE	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	ACH-000458	Skin Cancer	CCLE	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	ACH-000469	Brain Cancer	CCLE	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	ACH-002313	Lymphoma	CCLE	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	TE-8	oesophagus	COSMIC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	NMC-G1	central nervous system	COSMIC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	TK	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.R162H	YH-13	central nervous system	COSMIC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.P168T	TCGA-BS-A0UV	UCEC	TCGA	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.P168T	DO42793	UCEC	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.E195K	TCGA-C5-A1BI	CESC	TCGA	PPEY	ITCH	193:196	Mutation altering degron motif	0.591
p.E195K	DO44305	CESC	ICGC	PPEY	ITCH	193:196	Mutation altering degron motif	0.591
p.S184N	TCGA-CK-4951	COAD	TCGA	PPEY	ITCH	193:196	Mutation blocking phosphorylation signal	0.5278
p.S184N	DO10582	COAD	ICGC	PPEY	ITCH	193:196	Mutation blocking phosphorylation signal	0.5278
p.E173Q	TCGA-D8-A1JA	BRCA	TCGA	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.E173Q	DO2819	BRCA	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.P168S	TCGA-FS-A1ZC	SKCM	TCGA	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.P168S	DO37487	SKCM	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.Y172F	TCGA-G5-6233	READ	TCGA	PPTY	ITCH	169:172	Mutation altering degron motif	0.7528
p.Y172F	DO36626	READ	ICGC	PPTY	ITCH	169:172	Mutation altering degron motif	0.7528
p.P169L	TCGA-NJ-A4YF	LUAD	TCGA	PPTY	ITCH	169:172	Mutation altering degron motif	0.7582
p.P169L	DO218940	LUAD	ICGC	PPTY	ITCH	169:172	Mutation altering degron motif	0.7582
p.S204L	DO225159	BRCA	ICGC	PPEY	ITCH	193:196	Mutation rewiring degron network	0.1111
p.S204L	DO227790	BRCA	ICGC	PPEY	ITCH	193:196	Mutation rewiring degron network	0.1111
p.P168R	DO225244	BRCA	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.Q178H	DO233642	GACA	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1667
p.G177V	DO229029	LICA	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1944
p.R183M	DO229035	LICA	ICGC	PPEY	ITCH	193:196	Mutation rewiring degron network	0.0556
p.G177D	DO231072	LUSC	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1944
p.G177R	DO231072	LUSC	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.1944
p.D167Y	DO52124	PAEN	ICGC	PPTY	ITCH	169:172	Mutation rewiring degron network	0.2778
p.S164C	SIDM00864	Cervical Carcinoma	GDSC	PPTY	ITCH	169:172	Mutation blocking phosphorylation signal	0.6389
p.S164C	ACH-001341	Cervical Cancer	CCLE	PPTY	ITCH	169:172	Mutation blocking phosphorylation signal	0.6389
p.S164C	DoTc2-4510	cervix	COSMIC	PPTY	ITCH	169:172	Mutation blocking phosphorylation signal	0.6389
p.I199M	SIDM01609	Endometrial Carcinoma	GDSC	PPEY	ITCH	193:196	Mutation rewiring degron network	0.25
p.I199M	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	193:196	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRG1

UniProt ID: O14668

Entrez ID: 5638

Protein name: Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRG1 in