DegronMD - O14681(EI24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P326Q	TCGA-D3-A1Q3	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5556
p.P326Q	DO47509	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5556
p.P328L	TCGA-N7-A4Y0	UCS	TCGA	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.P328L	DO41199	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.E321D	DO229036	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.P327L	SIDM00504	Glioma	GDSC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.P327L	MOG-G-UVW	central nervous system	COSMIC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.S318P	SIDM00241	Breast Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6752
p.S318P	OCUB-M	breast	COSMIC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6752
p.P326L	ACH-001126	Brain Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5556
p.S317P	ACH-002179	Breast Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7863
p.L304R	RF-48	stomach	COSMIC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.S304P	OCUB-M	breast	COSMIC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.P313L	MOG-G-UVW	central nervous system	COSMIC	ALSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons