DegronMD - O14782(KIF3C)

FUNCTION: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.

GO - Biological processes (BP): microtubule-based movement [GO:0007018]; organelle transport along microtubule [GO:0072384]

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]

GO - Cellular component (CC): ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P422T	TCGA-CN-5361	HNSC	TCGA	PPGY	ITCH	418:421	Mutation rewiring degron network	0.3056
p.P422T	DO14329	HNSC	ICGC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.3056
p.P422L	TCGA-EE-A3J7	SKCM	TCGA	PPGY	ITCH	418:421	Mutation rewiring degron network	0.3056
p.P422L	DO48770	SKCM	ICGC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.3056
p.K413T	DO233174	GACA	ICGC	PPGY	ITCH	418:421	Mutation substituting flanking lysine	0.3056
p.E423G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.2778
p.E423G	ACH-002272	Lymphoma	CCLE	PPGY	ITCH	418:421	Mutation rewiring degron network	0.2778
p.E423G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.2778
p.V415M	SIDM00789	Colorectal Carcinoma	GDSC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	ACH-000938	Leukemia	CCLE	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	ACH-000997	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	ACH-001061	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	HCT-15	large intestine	COSMIC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.V415M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.25
p.A414T	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	418:421	Mutation rewiring degron network	0.2222
p.A414T	DO41235	UCEC	ICGC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.2222
p.V426A	TCGA-19-2621	GBM	TCGA	PPGY	ITCH	418:421	Mutation rewiring degron network	0.1944
p.V426A	DO11100	GBM	ICGC	PPGY	ITCH	418:421	Mutation rewiring degron network	0.1944
p.V426M	TCGA-AP-A059	UCEC	TCGA	PPGY	ITCH	418:421	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 28 entries

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Kaplan plot for KIF3C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF3C

UniProt ID: O14782

Entrez ID: 3797

Protein name: Kinesin-like protein KIF3C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF3C in