DegronMD - O14828(SCAMP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R47Q	TCGA-66-2755	LUSC	TCGA	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47Q	DO27365	LUSC	ICGC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47Q	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47Q	ACH-000072	Leukemia	CCLE	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47Q	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.P50L	TCGA-AP-A1DK	UCEC	TCGA	PPAY	ITCH	50:53	Mutation altering degron motif	0.7582
p.P50L	DO42033	UCEC	ICGC	PPAY	ITCH	50:53	Mutation altering degron motif	0.7582
p.P60S	TCGA-EE-A3JD	SKCM	TCGA	PPAY	ITCH	50:53	Mutation rewiring degron network	0.1389
p.P60S	DO50299	SKCM	ICGC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.1389
p.R47L	SIDM02021	Esophageal Carcinoma	GDSC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.P63S	SIDM00217	Colorectal Carcinoma	GDSC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.P63S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.P63S	SNU-1040	large intestine	COSMIC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.R47P	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47P	ACH-001138	Lung Cancer	CCLE	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R47P	NCI-H2141	lung	COSMIC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.A57T	SIDM00720	Mesothelioma	GDSC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.2222
p.A57T	ACH-000648	Lung Cancer	CCLE	PPAY	ITCH	50:53	Mutation rewiring degron network	0.2222
p.A57T	NCI-H28	pleura	COSMIC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.2222

Kaplan plot for SCAMP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAMP3

UniProt ID: O14828

Entrez ID: 10067

Protein name: Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAMP3 in