FUNCTION: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral ...
FUNCTION: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. {ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}.
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GO - Biological processes (BP):
adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; cell surface receptor signaling pathway [GO:0007166]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of B cell proliferation [GO:0030889]...
adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; cell surface receptor signaling pathway [GO:0007166]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of B cell proliferation [GO:0030889]
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GO - Molecular function (MF):
signaling receptor activity [GO:0038023]...
signaling receptor activity [GO:0038023]
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GO - Cellular component (CC):
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]...
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]
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