DegronMD - O14986(PIP5K1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y498S	TCGA-06-0132	GBM	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1389
p.Y498S	DO13450	GBM	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1389
p.T496I	TCGA-A5-A0GA	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0833
p.T496I	DO43763	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0833
p.T516I	TCGA-B5-A0K8	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1389
p.T516I	DO40831	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1389
p.G503R	TCGA-BF-A1PV	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.2778
p.G503R	DO47309	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.2778
p.S499L	TCGA-EE-A2GP	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499L	DO37422	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499L	SIDM00284	Melanoma	GDSC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499L	ACH-000805	Skin Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.S499L	COLO-679	skin	COSMIC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1667
p.E514K	TCGA-QK-AA3J	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1944
p.E514K	DO52101	HNSC	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1944
p.S501R	TCGA-YC-A89H	BLCA	TCGA	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.2222
p.S501R	DO51948	BLCA	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.2222
p.Y498N	DO228359	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.1389
p.L519F	SIDM00629	Breast Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.L519F	ACH-000573	Breast Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.L519F	MDA-MB-436	breast	COSMIC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0556
p.P505L	SIDM01696	Mesothelioma	GDSC	PSSST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7582
p.T509K	ACH-002048	Sarcoma	CCLE	PSSST	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7306

Kaplan plot for PIP5K1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIP5K1B

UniProt ID: O14986

Entrez ID: 8395

Protein name: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIP5K1B in