DegronMD - O15015(ZNF646)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A903T	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7139
p.A903T	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7139
p.S907C	TCGA-AC-A23H	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7541
p.S907C	DO2401	BRCA	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7541
p.R893W	TCGA-AX-A1CE	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.0556
p.R893W	DO42280	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.0556
p.G136D	TCGA-BG-A222	UCEC	TCGA	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.1111
p.G136D	DO42977	UCEC	ICGC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.1111
p.R901H	TCGA-KN-8428	KICH	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2778
p.R901H	DO220484	KICH	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2778
p.M909T	TCGA-MN-A4N4	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2778
p.M909T	DO26250	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2778
p.H899R	TCGA-QG-A5Z2	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2222
p.H899R	DO44096	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2222
p.T162M	DO222798	COCA	ICGC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.1667
p.E146K	DO234232	ESAD	ICGC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation altering degron motif	0.7022
p.W163L	DO229008	LICA	ICGC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.1389
p.S134G	DO50957	LICA	ICGC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.0556
p.P148L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation altering degron motif	0.6471
p.P148L	ACH-002240	Lymphoma	CCLE	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation altering degron motif	0.6471
p.P148L	H9	haematopoietic and lymphoid tissue	COSMIC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation altering degron motif	0.6471
p.S906T	SIDM00934	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.6005
p.S906T	SIDM00342	T-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.6005
p.S906Y	SIDM00934	Pancreatic Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.712
p.S906Y	SIDM00342	T-Lymphoblastic Leukemia	GDSC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.712
p.S906Y	LOUCY	haematopoietic and lymphoid tissue	COSMIC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.712
p.S906Y	CAPAN-1	pancreas	COSMIC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.712
p.A159P	SIDM00721	Small Cell Lung Carcinoma	GDSC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.25
p.A158V	SIDM00490	Glioma	GDSC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.2778
p.A158V	ACH-001016	Brain Cancer	CCLE	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.2778
p.A158V	Becker	central nervous system	COSMIC	TEETPDCESVPDP	DEG_COP1_1	144:156	Mutation rewiring degron network	0.2778
p.S906F	ACH-000247	Gastric Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	ACH-000984	Endometrial/Uterine Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	ACH-002197	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	ACH-002244	Head and Neck Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	HO-1-N-1	salivary gland	COSMIC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	OCUM-1	stomach	COSMIC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982
p.S906F	SBC-3	lung	COSMIC	AHSSS	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF646

UniProt ID: O15015

Entrez ID: 9726

Protein name: Zinc finger protein 646

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF646 in