DegronMD - O15146(MUSK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P479H	TCGA-EE-A181	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.P479H	DO37444	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.S482F	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.S482F	DO222908	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.S482F	DO37406	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.D474Y	TCGA-UF-A71D	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.D474Y	DO52109	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.V488I	TCGA-W3-AA1Q	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.V488I	DO219487	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.P476Q	DO224563	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.25
p.S480F	DO222402	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.6871
p.S480F	DO222632	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.6871
p.S484C	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.3056
p.S484C	ACH-002220	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.3056
p.S484C	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.3056
p.S483F	SIDM01190	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.S483F	ACH-000720	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.S483F	TCCSUP	urinary tract	COSMIC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7982
p.N488D	LNCaP-Clone-FGC	prostate	COSMIC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.S476C	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.25
p.S475F	TCCSUP	urinary tract	COSMIC	PSSSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.2222

Kaplan plot for MUSK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUSK

UniProt ID: O15146

Entrez ID: 4593

Protein name: Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUSK in