DegronMD - O15165(LDLRAD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G260D	TCGA-06-5416	GBM	TCGA	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.G260D	DO10880	GBM	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.H262Q	TCGA-17-Z017	LUAD	TCGA	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1389
p.Y255F	TCGA-51-4079	LUSC	TCGA	PPTY	ITCH	252:255	Mutation altering degron motif	0.7528
p.Y255F	DO26437	LUSC	ICGC	PPTY	ITCH	252:255	Mutation altering degron motif	0.7528
p.G264D	TCGA-AA-3672	COAD	TCGA	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.G264D	DO9010	COAD	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.P263Q	TCGA-D3-A2JO	SKCM	TCGA	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1111
p.P263Q	DO47619	SKCM	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1111
p.P186S	TCGA-DA-A95Y	SKCM	TCGA	PPPY	ITCH	180:183	Mutation rewiring degron network	0.25
p.P186S	DO223908	SKCM	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.25
p.P182S	TCGA-FD-A3SR	BLCA	TCGA	PPPY	ITCH	180:183	Mutation altering degron motif	0.5641
p.P182S	DO810	BLCA	ICGC	PPPY	ITCH	180:183	Mutation altering degron motif	0.5641
p.D193Y	TCGA-GC-A4ZW	BLCA	TCGA	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0556
p.D193Y	DO219024	BLCA	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0556
p.G260C	DO227646	COCA	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.A265T	DO222703	COCA	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0556
p.A265T	SIDM00118	Colorectal Carcinoma	GDSC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0556
p.A265T	ACH-001081	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0556
p.A265T	HCC2998	large intestine	COSMIC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.0556
p.S175F	DO222526	ESCA	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.1944
p.E178D	DO233951	GACA	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.2778
p.P263S	DO50898	LICA	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1111
p.P170T	DO231810	LINC	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0556
p.G177S	DO232045	ORCA	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.25
p.E249K	DO33960	PACA	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.25
p.E249Q	DO51493	PACA	ICGC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.25
p.T171A	DO38404	STAD	ICGC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0833
p.G246E	SIDM01175	Other Sarcomas	GDSC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1667
p.G246E	ACH-002309	Sarcoma	CCLE	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1667
p.G246E	SW684	soft tissue	COSMIC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1667
p.R247M	SIDM00255	Neuroblastoma	GDSC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.R247M	ACH-002282	Neuroblastoma	CCLE	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.R247M	NB17	autonomic ganglia	COSMIC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.T171N	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0833
p.T171N	ACH-000264	Lung Cancer	CCLE	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0833
p.T171N	Calu-6	lung	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0833
p.N245S	ACH-000953	Leukemia	CCLE	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1389
p.N245S	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1389
p.A188T	HCC2998	large intestine	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.1944
p.R192M	NB17	autonomic ganglia	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0833
p.N190S	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.1389
p.R170M	NB17	autonomic ganglia	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.0556
p.A247T	HCC2998	large intestine	COSMIC	PPTY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.G191E	SW684	soft tissue	COSMIC	PPPY	ITCH	180:183	Mutation rewiring degron network	0.1111

Kaplan plot for LDLRAD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LDLRAD4

UniProt ID: O15165

Entrez ID: 753

Protein name: Low-density lipoprotein receptor class A domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LDLRAD4 in