DegronMD - O15226(NKRF)

FUNCTION: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the... View more >>

GO - Biological processes (BP): negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]

GO - Molecular function (MF): ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]

GO - Cellular component (CC): nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D140A	DO219881	SKCA	ICGC	APSTT	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7793
p.A68E	DO228976	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	DO227848	PBCA	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.R69I	TCGA-2W-A8YY	CESC	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	TCGA-B5-A0JY	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	DO223732	CESC	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	DO43041	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.P70A	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25

Showing 1 to 20 of 39 entries

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Kaplan plot for NKRF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKRF

UniProt ID: O15226

Entrez ID: 55922

Protein name: NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NKRF in