DegronMD - O15226(NKRF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R69I	TCGA-2W-A8YY	CESC	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	TCGA-B5-A0JY	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	DO223732	CESC	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.R69I	DO43041	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.P58T	TCGA-DZ-6131	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1944
p.P58T	DO20911	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1944
p.R71C	TCGA-ZF-AA5N	BLCA	TCGA	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.R71C	DO219102	BLCA	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.G134V	DO50398	ESAD	ICGC	APSTT	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1667
p.A68E	DO228976	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.D150E	DO229037	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1667
p.A68V	DO227848	PBCA	ICGC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.A68V	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation blocking ubiquitination signal	0.75
p.D140A	DO219881	SKCA	ICGC	APSTT	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7793
p.P70A	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.P70A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.M147L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.D69A	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.D69A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.P55A	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.P55A	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.P55A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.P55A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.A53V	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.A53V	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.A53V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.A53V	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.M132L	ACH-000912	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1111

Kaplan plot for NKRF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKRF

UniProt ID: O15226

Entrez ID: 55922

Protein name: NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NKRF in