DegronMD - O15247(CLIC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R98M	TCGA-A5-A1OF	UCEC	TCGA	PPRY	ITCH	96:99	Mutation altering degron motif	0.7521
p.R98M	DO42568	UCEC	ICGC	PPRY	ITCH	96:99	Mutation altering degron motif	0.7521
p.T93S	TCGA-AG-A036	READ	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.25
p.T93S	DO37245	READ	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.25
p.E87Q	TCGA-AO-A03M	BRCA	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0833
p.E87Q	DO2216	BRCA	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0833
p.P96H	TCGA-AX-A1CE	UCEC	TCGA	PPRY	ITCH	96:99	Mutation altering degron motif	0.7694
p.P96H	DO42280	UCEC	ICGC	PPRY	ITCH	96:99	Mutation altering degron motif	0.7694
p.I86N	TCGA-AX-A2HA	UCEC	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.I86N	DO42504	UCEC	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.I86M	TCGA-BS-A0UF	UCEC	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.I86M	DO41488	UCEC	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.F89S	TCGA-BS-A0UJ	UCEC	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.1389
p.F89S	DO42745	UCEC	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.1389
p.S109Y	TCGA-BS-A0UV	UCEC	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.S109Y	TCGA-QF-A5YS	UCEC	TCGA	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.S109Y	DO52426	UCEC	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.S109Y	DO42793	UCEC	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.0556
p.P96S	DO222395	MELA	ICGC	PPRY	ITCH	96:99	Mutation altering degron motif	0.6752
p.P104S	DO222644	MELA	ICGC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.1944
p.E88K	SIDM01574	Plasma Cell Myeloma	GDSC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.1111
p.E88K	ACH-000588	Myeloma	CCLE	PPRY	ITCH	96:99	Mutation rewiring degron network	0.1111
p.P100H	SIDM00231	Kidney Carcinoma	GDSC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.3056
p.P100H	ACH-002167	Kidney Cancer	CCLE	PPRY	ITCH	96:99	Mutation rewiring degron network	0.3056
p.P100H	NCC010	kidney	COSMIC	PPRY	ITCH	96:99	Mutation rewiring degron network	0.3056

Kaplan plot for CLIC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLIC2

UniProt ID: O15247

Entrez ID: 1193

Protein name: Chloride intracellular channel protein 2 (XAP121)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLIC2 in