DegronMD - O15372(EIF3H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S3P	TCGA-AA-A01R	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.S3P	TCGA-AP-A1DK	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.K26R	TCGA-AJ-A3EL	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation substituting flanking lysine	0.1667
p.K26R	DO41542	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation substituting flanking lysine	0.1667
p.S3F	TCGA-EE-A2MJ	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.S15Y	TCGA-W5-AA39	CHOL	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.8231
p.S15T	TCGA-W5-AA39	CHOL	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7116
p.I9T	DO227507	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S17P	DO7934	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.75
p.S17P	DO42033	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.75
p.S10Y	DO227996	COCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.7222
p.S14C	DO225448	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7541
p.Q7K	DO228986	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.6389
p.P11T	DO233294	NACA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.75
p.S17F	DO38099	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.75
p.T8S	SIDM00993	Plasma Cell Myeloma	GDSC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.6667
p.T8S	AMO-1	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.6667
p.G9C	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.G9C	A427	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.S3C	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.S3C	KYSE-520	oesophagus	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.5278
p.G23C	ACH-000757	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1389
p.G23C	A427	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1389
p.T22S	ACH-000838	Myeloma	CCLE	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.T22S	AMO-1	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.S17C	KYSE-520	oesophagus	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation blocking phosphorylation signal	0.75

Kaplan plot for EIF3H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF3H

UniProt ID: O15372

Entrez ID: 8667

Protein name: Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF3H in