DegronMD - O15444(CCL25)

CCL25

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S141F	TCGA-2W-A8YY	CESC	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation blocking phosphorylation signal	0.6389
p.V140I	TCGA-AJ-A3OJ	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.K137N	TCGA-CN-6021	HNSC	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.A146G	TCGA-D6-A6EN	HNSC	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L142F	TCGA-YG-AA3N	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.I144M	TCGA-YT-A95E	THYM	TCGA	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.S140F	DO223732	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.K136N	DO15847	HNSC	ICGC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6918
p.A145G	DO223266	HNSC	ICGC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.L141F	DO51298	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation blocking phosphorylation signal	0.6389
p.V139I	DO42753	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.S145L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.S145L	ACH-002171	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.S145L	NCI-H250	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.S144L	NCI-H250	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc