DegronMD - O15479(MAGEB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A49D	TCGA-A5-A0G1	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7793
p.A49D	DO42472	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7793
p.S97P	TCGA-A5-A0G1	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.S97P	DO42472	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.R113M	TCGA-D3-A2JN	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.R113M	DO47590	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.T112A	TCGA-DI-A1BU	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.T112A	DO42023	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.L111P	TCGA-E6-A1LX	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1111
p.L111P	DO41020	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1111
p.S46Y	TCGA-EO-A22U	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.25
p.S46Y	DO43755	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.25
p.E108K	TCGA-VS-A8QM	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E108K	TCGA-W3-A824	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E108K	DO51631	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E108K	DO220877	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E108K	DO222898	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E108K	DO51271	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E61K	DO229010	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.E61K	DO229016	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.E61K	DO229003	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.E61K	DO229005	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.E61K	DO231070	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.A50S	DO48328	ESCA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.6477
p.G90V	DO229018	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.V45F	DO229025	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.S97Y	DO231127	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.A49P	DO26512	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.6392
p.Q63L	DO233298	NACA	ICGC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.C41Y	SIDM00582	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.C41Y	SIDM00584	Osteosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.C41Y	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.C41Y	SIDM00687	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.C41Y	SIDM01728	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.C41Y	SIDM00162	Biliary Tract Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.P54L	SIDM01104	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.P54L	ACH-000640	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.P54L	SK-MEL-31	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.T103A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.T103A	SIDM00317	Kidney Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.T103A	SIDM00146	Breast Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.T103A	SIDM00539	Esophageal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.T103A	SIDM00863	Burkitt's Lymphoma	GDSC	ASTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.Q98H	ACH-000545	Bladder Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.3056
p.S96F	ACH-000691	Breast Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEB2

UniProt ID: O15479

Entrez ID: 4113

Protein name: Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGEB2 in