DegronMD - O15524(SOCS1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A35T	TCGA-GS-A9TZ	DLBC	TCGA	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.A35T	DO219918	DLBC	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.A17T	DO234230	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.A17T	DO27851	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.A17T	DO228236	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.A16P	DO27851	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.A16P	DO228294	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.A16T	DO27779	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.A16T	DO228451	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.P19R	DO228353	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.P19A	DO228353	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.A16S	DO52675	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.P25L	DO228451	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.7582
p.E24Q	DO228451	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.3056
p.E18Q	DO228465	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1389
p.T15R	DO221123	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0556
p.P36A	DO232445	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1389
p.R38H	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.R38H	ACH-000983	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0833
p.S28F	ACH-000290	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.7982
p.R22Q	ACH-000519	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.25
p.S27Y	ACH-000939	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.712

Kaplan plot for SOCS1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOCS1

UniProt ID: O15524

Entrez ID: 8651

Protein name: Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SOCS1 in