DegronMD - O43150(ASAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R790Q	TCGA-AA-3984	COAD	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1111
p.R790Q	DO9002	COAD	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1111
p.P786L	TCGA-AJ-A3OJ	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P786L	DO42753	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P786L	ACH-000476	Liver Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P786L	JHH-4	liver	COSMIC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P779H	TCGA-BS-A0UM	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.6583
p.P779H	DO43065	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.6583
p.P785L	TCGA-EB-A431	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.25
p.P785L	DO37671	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.25
p.P785L	SIDM00654	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.25
p.P785L	ACH-000866	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.25
p.P785L	NCI-H1048	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.25
p.P776S	TCGA-EE-A17X	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.P776S	DO37931	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.P786S	TCGA-EE-A2MR	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P786S	DO37819	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P788H	TCGA-EO-A22U	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.P788H	TCGA-EO-A3AU	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.P788H	DO43827	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.P788H	DO43755	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.A784T	DO234336	ESAD	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.A778S	DO232224	PBCA	ICGC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7588
p.A774T	SIDM01943	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.A774T	SIDM00185	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.A774T	SIDM01650	Non-Cancerous	GDSC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.A774T	ACH-002354	Non-Cancerous	CCLE	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.P776L	SIDM01619	Endometrial Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.P776L	ACH-000984	Endometrial/Uterine Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778

Kaplan plot for ASAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASAP2

UniProt ID: O43150

Entrez ID: 8853

Protein name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASAP2 in